Evidence map›Paper›PMID 41451864›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Associations between cerebral blood transit time, amyloid-β pathology and cognitive decline in non-demented older adults.

Yao Zhang, Xiao Luo, Hui Hong, Ruiting Zhang, Shuyue Wang, Lingyun Liu, Miao Lin, Kaicheng Li, Qingze Zeng, Yanxing Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yao ZhangDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiao LuoDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Hui HongDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Ruiting ZhangDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Shuyue WangDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Lingyun LiuDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Miao LinDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Kaicheng LiDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Qingze ZengDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yanxing ChenDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jianzhong SunDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Peiyu HuangDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID 0000-0003-4226-9369

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
DOD ADNI W81XWH-12-2-0012National Natural Science Foundation of China 82271936National Natural Science Foundation of China 82371190National Natural Science Foundation of China 82371907Natural Science Foundation of Zhejiang Province LZ24H180002NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

introductionThe contribution of cerebrovascular hemodynamic disturbances to Alzheimer's disease (AD) remains unclear. Using time-shift analysis of blood-oxygenation-level-dependent (BOLD) signals, we explored associations between cerebral blood transit time, amyloid beta (Aβ) pathology, and cognition.

methodsWe included 131 non-demented individuals from the Alzheimer's Disease Neuroimaging Initiative. Three transit metrics - termed Lag

resultsAt baseline, prolonged Lag DISCUSSION: Prolonged blood transit time can reflect early vascular impairment in AD. HIGHLIGHTS: Vascular risks are associated with prolonged arterial transit time (Lag

Indexed as

Amyloid beta-PeptidesBrainCerebrovascular CirculationCognitive DysfunctionAgedAged, 80 and overCross-Sectional StudiesFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleAmyloid beta-PeptidesAlzheimer's diseaseblood‐oxygenation‐level‐dependentblood transit timecognitive impairmenttime‐shift analysis

Identifiers

PMID41451864
PMCPMC12741934

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.