Evidence map›Paper›PMID 41452264›Full record

ArticleJournal of neurochemistry2025

Convergent Recruitment of Cerebellar Purkinje Cells by Mechanistically Diverse General Anesthetics.

Nozomi Utsumi, Daisuke H Tanaka, Ayaka Nakai, Shizuki Inaba, Shigenori Nonaka, Shigeru Maeda, Naofumi Uesaka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nozomi UtsumiDepartment of Cognitive Neurobiology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Daisuke H TanakaDepartment of Cognitive Neurobiology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Ayaka NakaiDepartment of Cognitive Neurobiology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Shizuki InabaDepartment of Cognitive Neurobiology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Shigenori NonakaSpatiotemporal Regulations Group, Exploratory Research Center for Life and Living Systems, Okazaki, Aichi, Japan.
Shigeru MaedaDepartment of Dental Anesthesiology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Naofumi UesakaDepartment of Cognitive Neurobiology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID 0000-0002-9744-944X

Funding

Japan Science and Technology AgencyJapan Society for the Promotion of Science 22H05093Japan Society for the Promotion of Science 25K02375Japan Society for the Promotion of Science JP16H06280Joint research of the Exploratory research center on life and living systems program 21-318Lotte FoundationNIBB Collaborative Research Program 22NIBB517NIBB Collaborative Research Program 23NIBB514NIBB Collaborative Research Program 24NIBB526NIBB Collaborative Research Program 25NIBB501Tokyo Medical and Dental University
6 · The paper itself

Abstract

General anesthesia produces a rapid and reversible loss of consciousness, yet the neural circuits through which chemically unrelated agents achieve this state remain largely unknown. Here, we combined Targeted Recombination in Active Populations (TRAP), Clear, Unobstructed Brain/Body Imaging Cocktails and Computational analysis (CUBIC) tissue clearing, and light-sheet microscopy to generate a hemisphere-wide, single-cell atlas of neurons activated by three mechanistically distinct anesthetics in adult Fos

Indexed as

Anesthetics, GeneralCerebellumPurkinje CellsAnimalsFemaleMiceMice, Inbred C57BLMice, TransgenicAnesthetics, General

Identifiers

PMID41452264
PMCPMC12742451

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.