ReviewCurrent atherosclerosis reports2025
Fibrates : Do They Still Have a Role in Therapy in 2025?
Review in Current atherosclerosis reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Review
- Targeting triglycerides for cardiovascular risk reduction.Internal and emergency medicine · 2026Review
- Hypertriglyceridaemia-Associated Acute Pancreatitis: Risk Stratification, Drivers, and Prevention of Recurrence.Diseases (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewAtherosclerotic cardiovascular disease (ASCVD) remains a leading cause of mortality despite optimal LDL-C control, leaving substantial residual risk in patients with atherogenic dyslipidaemia. This review re-examines the evolving role of fibrates in the management of dyslipidaemia, metabolic dysfunction-associated steatotic liver disease (MASLD), chronic kidney disease (CKD), and diabetic microvascular complications. RECENT
findingsLarge trials have demonstrated modest or inconsistent cardiovascular benefits with fibrates, with effects mainly limited to patients with elevated triglycerides and low HDL-C. The PROMINENT trial confirmed that lowering triglycerides alone does not improve cardiovascular outcomes. However, emerging evidence suggests that fibrates, particularly fenofibrate and pemafibrate, have beneficial effects on albuminuria, hepatic steatosis, and diabetic retinopathy, indicating pleiotropic metabolic benefits beyond lipid lowering. Fibrates remain therapeutically relevant in selected dyslipidaemic or metabolically altered phenotypes. Their future lies in precision metabolic therapy, targeting microvascular, hepatic, and renal complications within a personalised cardiometabolic approach.
Indexed as
Identifiers
41452383What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.