Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Klevis Ndoj *Department of Medical Biochemistry, Amsterdam University Medical Centers location AMC, University of Amsterdam, Amsterdam 1105AZ, The Netherlands.ORCID 0009-0002-5902-7673
Matteo Tantucci *Center for Molecular Medicine-Cell Biology, University Medical Center Utrecht, University of Utrecht, Utrecht 3584CX, The Netherlands.
Paolo SanzaCenter for Molecular Medicine-Cell Biology, University Medical Center Utrecht, University of Utrecht, Utrecht 3584CX, The Netherlands.ORCID 0009-0006-5934-7457
Kristian ZubakDepartment of Medical Biochemistry, Amsterdam University Medical Centers location AMC, University of Amsterdam, Amsterdam 1105AZ, The Netherlands.
Giorgia MarodinDepartment of Medical Biochemistry, Amsterdam University Medical Centers location AMC, University of Amsterdam, Amsterdam 1105AZ, The Netherlands.ORCID 0009-0008-2626-625X
Jenina KingmaDepartment of Medical Biochemistry, Amsterdam University Medical Centers location AMC, University of Amsterdam, Amsterdam 1105AZ, The Netherlands.ORCID 0000-0003-2822-5415
Felix SnijderDepartment of Medical Biochemistry, Amsterdam University Medical Centers location AMC, University of Amsterdam, Amsterdam 1105AZ, The Netherlands.
Tineke VeenendaalCenter for Molecular Medicine-Cell Biology, University Medical Center Utrecht, University of Utrecht, Utrecht 3584CX, The Netherlands.ORCID 0009-0000-4179-1556
Daniel L KoberDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0001-8657-9348
Noam Zelcer *Department of Medical Biochemistry, Amsterdam University Medical Centers location AMC, University of Amsterdam, Amsterdam 1105AZ, The Netherlands.ORCID 0000-0001-6935-7532
Judith Klumperman *Center for Molecular Medicine-Cell Biology, University Medical Center Utrecht, University of Utrecht, Utrecht 3584CX, The Netherlands.
Funding
Structural and mechanistic basis for the maturation of site-one protease in the secretory pathwayR01GM155152 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Daniel Luke Kober · 2024 to 2026
$1.0M
The mechanistic basis for targeted protein degradation in lipid metabolismR00GM141261 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI KOBER, DANIEL LUKE · 2023 to 2025
$747k
EC | Horizon Europe | Excellent Science | HORIZON EUROPE Marie Sklodowska-Curie Actions (MSCA) 953489HHS | NIH (NIH) R00GM141261HHS | NIH (NIH) R01GM155152Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) 016.176.643Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) 184.034.014NIGMS NIH HHS R00 GM141261NIGMS NIH HHS R01 GM155152NWO | Exacte en Natuurwetenschappen (ENW) M.22.034Welch Foundation (The Welch Foundation) I-2246-20250403ZonMw (Netherlands Organisation for Health Research and Development) 09120242410013
6 · The paper itself
Abstract
The Niemann-Pick type 1 and 2 proteins (NPC1 and NPC2) coordinate cholesterol egress from late endosomes-lysosomes (LE/LY). Proper folding, trafficking, and localization of both NPC proteins are essential for normal LE/LY cholesterol handling. Accordingly, mutations in
Indexed as
CholesterolEndosomesLysosomal Membrane ProteinsVesicular Transport ProteinsHeLa CellsHomeostasisHumansIntracellular Signaling Peptides and ProteinsLysosomal-Associated Membrane Protein 1LysosomesNiemann-Pick C1 ProteinNiemann-Pick Disease, Type CProtein TransportCholesterolIntracellular Signaling Peptides and ProteinsLAMP1 protein, humanLysosomal-Associated Membrane Protein 1Lysosomal Membrane ProteinsNiemann-Pick C1 ProteinNPC1 protein, humanVesicular Transport ProteinsVPS41 protein, humancholesterol metabolismintracellular cholesterol transportlysosomesNPC1VPS41
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.