ArticleThe Journal of allergy and clinical immunology2026
CCR8
Article in The Journal of allergy and clinical immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
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Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundAllergic asthma is characterized by dysregulated type 2 immunity to environmental antigens. However, our knowledge is limited regarding how type 2 immune responses are regulated during chronic airway inflammation. CD4
objectiveThis study aimed to identify the population of Treg cells that play a key role in regulating allergen-induced type 2 immune responses.
methodsNaive mice were intranasally exposed to fungus Alternaria alternata extract or house dust mite for up to 6 weeks. We characterized the phenotypes, tissue localization, and temporal dynamics of Treg cell subpopulations. In vivo functions were assessed using mice deficient in Treg cells or Ccr8, as well as wild-type mice treated with anti-IL-10R blocking antibody.
resultsDepletion of Treg cells or blockade of the IL-10 pathway exacerbated type 2 airway inflammation in mice exposed to Alternaria. Multiple Treg cell subsets were identified in the lungs after Alternaria exposure. Among them, CCR8
conclusionTissue-resident CCR8
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Registered trials
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