Evidence map›Paper›PMID 41453498›Full record

ArticleBrain research bulletin2026

Cerebellar deep brain stimulation rescues Purkinje cell mitochondrial density in a genetic mouse model of cerebellar ataxia.

Lauren N Miterko-Myers, Lauren E Peacoe, Lita Duraine, Zhongyuan Zuo, Roy V Sillitoe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lauren N Miterko-MyersDepartment of Pathology and Immunology, Baylor College of Medicine, USA; Program in Developmental Biology, Baylor College of Medicine, USA; Cerebellum Science Center, Texas Children's Hospital, USA. Electronic address: lmiterko@austincollege.edu.
Lauren E PeacoeDepartment of Pathology and Immunology, Baylor College of Medicine, USA; Department of Neuroscience, Baylor College of Medicine, USA; Cerebellum Science Center, Texas Children's Hospital, USA; Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, TX 77030, USA.
Lita DuraineDepartment of Pathology and Immunology, Baylor College of Medicine, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, USA; Cerebellum Science Center, Texas Children's Hospital, USA; Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, TX 77030, USA.
Zhongyuan ZuoDepartment of Pathology and Immunology, Baylor College of Medicine, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, USA; Cerebellum Science Center, Texas Children's Hospital, USA.
Roy V SillitoeDepartment of Pathology and Immunology, Baylor College of Medicine, USA; Department of Neuroscience, Baylor College of Medicine, USA; Department of Pediatrics, Baylor College of Medicine, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, USA; Program in Developmental Biology, Baylor College of Medicine, USA; Development, Disease Models & Therapeutics Graduate Program, Baylor College of Medicine, USA; Cerebellum Science Center, Texas Children's Hospital, USA; Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston, TX 77030, USA. Electronic address: sillitoe@bcm.edu.

Funding

Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8M
Cerebellar Deep Brain StimulationR01NS119301 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SILLITOE, ROY VINCENT · 2020 to 2024
$2.0M
Spatial and temporal pathophysiology of developmental dystoniaR01NS127435 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Roy Vincent Sillitoe · 2022 to 2026
$2.0M
NICHD NIH HHS U54 HD083092NINDS NIH HHS R01 NS119301NINDS NIH HHS R01 NS127435
6 · The paper itself

Abstract

Deep brain stimulation (DBS) improves motor function in a growing list of movement diseases including Parkinson's disease, dystonia, and tremor. There is evidence that DBS may also be effective in ataxia. It is not known why DBS is effective, but modulating cell activity and conferring neuroprotection are hypothesized to underlie its benefits. Understanding the effects of DBS on neurons is paramount to extending its clinical use in the treatment of various motor and non-motor diseases. Here, we stimulated the cerebellum of Car8 waddles (Car8

Indexed as

Cerebellar AtaxiaCerebellumDeep Brain StimulationMitochondriaPurkinje CellsAnimalsDisease Models, AnimalEndoplasmic ReticulumMaleMiceCAR8CerebellumDeep Brain StimulationEndoplasmic ReticulumMitochondriaPurkinje cellTransmission Electron Microscopy

Identifiers

PMID41453498
PMCPMC13314846

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.