ArticleJournal of molecular and cellular cardiology2026
Phenotypes and mechanisms of dysfunctional cardiac T-lymphocytes in dilated cardiomyopathy patients.
Article in Journal of molecular and cellular cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDilated cardiomyopathy (DCM) is characterized by increased infiltration and activation of the innate immune system, including neutrophils, monocytes/macrophages, and dendritic cells. However, the phenotypic profile of cardiac CD3
methodsWe studied phenotypic signatures of T-cell subsets by analyzing publicly available single-cell and single-nuclear transcriptomic datasets from control and failing hearts of DCM patients.
resultsOur analysis revealed increased cardiac infiltration of CD3
conclusionHere we demonstrate for the first time, an "activated phenotype" with increased pro-inflammatory and profibrotic signaling in cardiac CD3
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