Evidence map›Paper›PMID 41453577›Full record

ArticleNeurobiology of disease2026

APOE4 reduces hippocampal expression of phosphoglycerate kinase 1 and sodium potassium pump to enhance seizure susceptibility in mice.

Tanveer Singh, Emma Bridgeman, Annie J Baker, Hayden A Noblet, Kang Yi Yang, Sehong Kang, Ki H Lim, Sarah S Lee, Nicolette M Amundsen, Yongjae Lee and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tanveer SinghDept. of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, 407 South Goodwin Avenue, 524 Burrill Hall, Urbana, IL 61801, USA.
Emma BridgemanDept. of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, 407 South Goodwin Avenue, 524 Burrill Hall, Urbana, IL 61801, USA.
Annie J BakerDept. of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, 407 South Goodwin Avenue, 524 Burrill Hall, Urbana, IL 61801, USA.
Hayden A NobletDept. of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, 407 South Goodwin Avenue, 524 Burrill Hall, Urbana, IL 61801, USA.
Kang Yi YangDept. of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, 407 South Goodwin Avenue, 524 Burrill Hall, Urbana, IL 61801, USA.
Sehong KangDept. of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, 1206 W. Green St., MC 244 Sidney Lu Mechanical Engineering Building, Urbana, IL 61801, USA.
Ki H LimDept. of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, 407 South Goodwin Avenue, 524 Burrill Hall, Urbana, IL 61801, USA.
Sarah S LeeDept. of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, 407 South Goodwin Avenue, 524 Burrill Hall, Urbana, IL 61801, USA.
Nicolette M AmundsenDept. of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, 407 South Goodwin Avenue, 524 Burrill Hall, Urbana, IL 61801, USA.
Yongjae LeeDept of Physics, University of Illinois at Urbana-Champaign, 1110 West Green Street, Loomis Laboratory of Physics, Urbana, IL 61801, USA; The Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, 1110 West Green Street, Loomis Laboratory of Physics, Urbana, IL 61801, USA.
Paul R SelvinDept of Physics, University of Illinois at Urbana-Champaign, 1110 West Green Street, Loomis Laboratory of Physics, Urbana, IL 61801, USA; The Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, 1110 West Green Street, Loomis Laboratory of Physics, Urbana, IL 61801, USA.
Hyunjoon KongDept of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, 114, Roger Adams Laboratory, Urbana, IL 61801, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 W Gregory Dr, Urbana, IL 61801, USA; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 N Mathews Ave, Urbana, IL 61801, USA.
Hee Jung ChungDept. of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, 407 South Goodwin Avenue, 524 Burrill Hall, Urbana, IL 61801, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 W Gregory Dr, Urbana, IL 61801, USA; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 N Mathews Ave, Urbana, IL 61801, USA. Electronic address: chunghj@illinois.edu.

Funding

Super-Resolution Microscopy of Neuronal Synapses with Small Quantum Dots and Advanced Imaging ToolsR01NS100019 · NINDS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CHUNG, HEE JUNG, SELVIN, PAUL R · 2017 to 2025
$3.2M
Super-Resolution Fluorescence Microscopy of Synaptic Plasticity on Unmodified Brain Slices in Health and TauopathyRF1AG083625 · NIA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CHUNG, HEE JUNG, SELVIN, PAUL R · 2023 to 2023
$1.9M
Dynamic changes in PIP2 binding sites and their impact on axonal targeting and function of epilepsy-associated KCNQ/Kv7 channelsR01NS126584 · NINDS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Hee Jung Chung · 2023 to 2026
$1.5M
NIA NIH HHS RF1 AG083625NINDS NIH HHS R01 NS100019NINDS NIH HHS R01 NS126584
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the leading cause of dementia, characterized by the deposition of amyloid-β plaques and neurofibrillary tangles composed of hyperphosphorylated tau. Seizures have also emerged as a prevalent clinical feature of AD and are associated with APOE4, the major genetic risk factor of AD. However, the mechanism by which APOE4 induces seizures and neuronal hyperexcitability is incompletely understood. We discovered that human APOE4 targeted replacement mice showed increased seizure severity and seizure-induced death at 5.5-7 but not 2-3 months of age compared to APOE3 mice using the kainic acid model of status epilepticus which preferentially arises from the hippocampus. While Tau burden alone did not alter seizure susceptibility in mice, APOE4 together with Tau burden enhanced seizure severity in female mice. Notably, APOE4 was associated with decreased hippocampal levels of sodium/potassium-ATPase, ATP-generating glycolytic enzymes, including phosphoglycerate kinase 1 (PGK1) and pyruvate kinase M, and ATP. While inhibition of Na

Indexed as

Apolipoprotein E4HippocampusPhosphoglycerate KinaseSeizuresSodium-Potassium-Exchanging ATPaseAnimalsDisease Models, AnimalFemaleHumansKainic AcidMaleMiceMice, Inbred C57BLMice, TransgenicStatus Epilepticustau ProteinsApolipoprotein E4Kainic AcidPhosphoglycerate KinaseSodium-Potassium-Exchanging ATPasetau ProteinsAlzheimer's diseaseAPOE4ATPPGK1Sodium/potassium-ATPaseStatus epilepticusTau

Identifiers

PMID41453577
PMCPMC13118231

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.