Evidence map›Paper›PMID 41453833›Full record

ReviewJournal of the European Academy of Dermatology and Venereology : JEADV2026

Dermatology 2.0: Precision medicine for inflammatory skin diseases.

Jeremy Di Domizio, Antoine Girardin, Curdin Conrad, Teofila Seremet, Michel Gilliet

Abstract readReview
In one paragraph

Review in Journal of the European Academy of Dermatology and Venereology : JEADV, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Oral lichenoid lesions in CTLA-4 haploinsufficiency: Targeting IFN-γ-driven mucosal immunopathology.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Article
  2. Reframing molecular superiority in the differential diagnosis of eczema and psoriasis.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Article
  3. Molecular differentiation of psoriasis and eczema: Reference standards and benchmarking caveats.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Article
  4. Article
  5. Bridging theory and practice in model-informed precision dosing of medication in inflammatory skin diseases.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jeremy Di DomizioDepartment of Dermatology, CHUV University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-6281-3918
Antoine GirardinDepartment of Dermatology, CHUV University Hospital and University of Lausanne, Lausanne, Switzerland.
Curdin ConradDepartment of Dermatology, CHUV University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-2547-3440
Teofila SeremetDepartment of Dermatology, CHUV University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-3789-6256
Michel GillietDepartment of Dermatology, CHUV University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-4609-3762

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 310030_204835Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 310030B_182834Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 4078P0_198470
6 · The paper itself

Abstract

Recent advances in immunology and transcriptomics have transformed dermatology, redefining inflammatory skin diseases as distinct molecular entities characterized by dominant immune pathways such as Th17, Th2, Th1, type I interferon (IFN) and myeloid modules. We transcriptionally delineated these immune modules, constructed a reference immune cartography to map patient skin biopsies and developed a digital platform that enables clinicians to analyse individual molecular profiles, facilitating precise diagnosis for clinically overlapping or diagnostically ambiguous dermatoses. Beyond diagnostic utility, this platform supports therapeutic decision-making by aligning each patient's dominant immune module with the most appropriate targeted treatment. Analyses of treatment failures reveal that discordance between therapy and immune module dominance, as well as immune shifts between modules, account for most cases of non-response. Realigning therapy with the patient's molecular profile restores efficacy and enables rational adaptation or repurposing of existing agents. By integrating molecular diagnostics with immune module-guided therapy, this approach establishes a precision medicine framework that optimizes outcomes and advances personalized care for patients with inflammatory skin disease.

Indexed as

DermatitisDermatologyPrecision MedicineSkin DiseasesHumansbullous pemphigoidchronic hand eczemaDarier's diseasedigital platformdrug hypersensitivity reactionsimmune moduleslichen planuslupusmolecular profilingmycosis fungoidespalmoplantar pustular psoriasisprecision medicinepsoriasisatopic dermatitis

Identifiers

PMID41453833
PMCPMC12933700

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.