Evidence map›Paper›PMID 41453861›Full record

ArticleNature communications2025

Lymphatic-stem cell crosstalk promotes tendon regeneration via Notch1-Srebp2-mediated cholesterol metabolism.

Liujing Chen, Meilian Cai, Shuai Lin, Mingzhao Li, Zilu Zhu, Han Zhang, Hu Zhao, Chun Xu, Ruili Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Liujing Chen *Department of Orthodontics, Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key Laboratory for Dental Materials, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School and Hospital of Stomatology, Beijing, China.
Meilian Cai *Department of Orthodontics, Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key Laboratory for Dental Materials, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School and Hospital of Stomatology, Beijing, China.
Shuai LinDepartment of Orthodontics, Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key Laboratory for Dental Materials, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School and Hospital of Stomatology, Beijing, China.
Mingzhao LiDepartment of Orthodontics, Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key Laboratory for Dental Materials, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School and Hospital of Stomatology, Beijing, China.ORCID http://orcid.org/0009-0006-7212-0820
Zilu ZhuDepartment of Orthodontics, Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key Laboratory for Dental Materials, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School and Hospital of Stomatology, Beijing, China.
Han ZhangDepartment of Orthodontics, Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key Laboratory for Dental Materials, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School and Hospital of Stomatology, Beijing, China.
Hu ZhaoChinese Institute for Brain Research, Beijing, China.ORCID http://orcid.org/0000-0002-2961-0086
Chun XuFaculty of Medicine and Health, Sydney Dental School, The University of Sydney, Camperdown, NSW, Australia.
Ruili YangDepartment of Orthodontics, Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key Laboratory for Dental Materials, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School and Hospital of Stomatology, Beijing, China. ruiliyang@bjmu.edu.cn.ORCID http://orcid.org/0000-0002-3283-9893

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tendons, as bradytrophic tissues, exhibit limited healing capacity. The role of lymphatic vessels in tendon regeneration is largely overlooked. By comparing gene expression of the control and injured tendon cells from both neonatal and adult mice, we identify lymphatic vessels as key regenerative niche elements. Using the Transparent Embedding Solvent System for clearing in Prox1-Cre

Indexed as

CholesterolLymphatic VesselsReceptor, Notch1RegenerationStem CellsTendonsAdaptor Proteins, Signal TransducingAnimalsCell Adhesion Molecules, NeuronalEndothelial CellsExtracellular Matrix ProteinsHomeodomain ProteinsMaleMiceMice, Inbred C57BLMice, KnockoutAdaptor Proteins, Signal TransducingCell Adhesion Molecules, NeuronalCholesterolDab1 protein, mouseExtracellular Matrix ProteinsHomeodomain ProteinsNerve Tissue ProteinsNotch1 protein, mouseProspero-Related Homeobox 1 ProteinReceptor, Notch1Receptors, LDLReelin ProteinReln protein, mouseSerine EndopeptidasesTumor Suppressor ProteinsVLDL receptor

Identifiers

PMID41453861
PMCPMC12855879

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.