ArticleFrontiers of medicine2025
Prognostic value of ultrafiltration rate variability in maintenance hemodialysis patients: a prospective cohort study.
Article in Frontiers of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This single-center prospective cohort study establishes ultrafiltration rate variability (quantified by coefficient of variation, UFRCV) as an independent predictor of all-cause and cardiovascular mortality in maintenance hemodialysis patients. While absolute ultrafiltration rate thresholds represent established risk factors, dynamic fluid removal fluctuations remain prognostically uncharacterized. We longitudinally monitored ultrafiltration rate patterns during a 90-day observation period in 202 hemodialysis patients (median follow-up: 38.7 months). Stratification by median UFRCV (0.187) revealed significantly reduced survival among patients with elevated variability. This association demonstrated particular clinical significance in elderly individuals (> 60 years), those with recurrent intradialytic hypotension, and subjects exhibiting elevated predialysis systolic blood pressure variability. Notably, UFRCV exhibited stronger mortality prediction in patients with lower mean ultrafiltration volumes (< 2469 mL), indicating that current static ultrafiltration rate targets inadequately reflect dynamic hemodynamic vulnerability. These findings underscore the imperative to integrate ultrafiltration rate variability metrics into personalized volume management frameworks-a parameter currently absent from dialysis adequacy guidelines. Collectively, UFRCV assessment emerges as a critical indicator of subclinical hemodynamic compromise, providing pivotal insights for refining hemodynamic risk stratification in maintenance hemodialysis populations.
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41454072What Socratic holds
Registered trials
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