Evidence map›Paper›PMID 41454073›Full record

ArticleFrontiers of medicine2025

Association of oral frailty and gut microbiota with hypertension: cross-sectional results in the Shika study.

Fumihiko Suzuki, Ren Mizoguchi, Shigehiro Karashima, Yasuo Ikagawa, Hiromasa Tsujiguchi, Akinori Hara, Sakae Miyagi, Thao Thi Thu Nguyen, Atsushi Asai, Koji Katano and 12 more

Abstract read
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In one paragraph

Article in Frontiers of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Fumihiko SuzukiDepartment of Geriatric Dentistry, Ohu University School of Dentistry, Koriyama, 963-8041, Japan. f-suzuki@den.ohu-u.ac.jp.
Ren MizoguchiDepartment of Health Promotion and Medicine of the Future, Kanazawa University, 13-1 Takaramachi, Kanazawa, Japan.
Shigehiro KarashimaInstitute of Liberal Arts and Science, Kanazawa University, Kanazawa, 920-8640, Japan.
Yasuo IkagawaLaboratory of Medical Microbiology and Microbiome, Department of Clinical Laboratory and Biomedical Sciences, Division of Health Sciences, Graduate School of Medicine, University of Osaka, Osaka, 565-0871, Japan.
Hiromasa TsujiguchiDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-8640, Japan.
Akinori HaraDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-8640, Japan.
Sakae MiyagiInnovative Clinical Research Center, Kanazawa University, Kanazawa, 920-8641, Japan.
Thao Thi Thu NguyenFaculty of Public Health, Haiphong University of Medicine and Pharmacy, Hai Phong, 180000, Vietnam.
Atsushi AsaiEnvironmental Stress Research Center, Kanazawa University, Kanazawa, 920-8640, Japan.
Koji KatanoEnvironmental Stress Research Center, Kanazawa University, Kanazawa, 920-8640, Japan.
Tomoko KasaharaEnvironmental Stress Research Center, Kanazawa University, Kanazawa, 920-8640, Japan.
Kuniko SatoEnvironmental Stress Research Center, Kanazawa University, Kanazawa, 920-8640, Japan.
Masaharu NakamuraDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-8640, Japan.
Yukari ShimizuFaculty of Health Sciences, Department of Nursing, Komatsu University, Komatsu, 923-0961, Japan.
Aki ShibataDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-8640, Japan.
Keita SuzukiEnvironmental Stress Research Center, Kanazawa University, Kanazawa, 920-8640, Japan.
Takayuki KannonDepartment of Biomedical Data Science, School of Medicine, Fujita Health University, Toyoake, 470-1192, Japan.
Noriyoshi OginoDepartment of Environmental Medicine, Faculty of Medicine, Kochi University, Nankoku, 783-8505, Japan.
Hirohito TsuboiDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-8640, Japan.
Atsushi TajimaEnvironmental Stress Research Center, Kanazawa University, Kanazawa, 920-8640, Japan.
Shigefumi OkamotoLaboratory of Medical Microbiology and Microbiome, Department of Clinical Laboratory and Biomedical Sciences, Division of Health Sciences, Graduate School of Medicine, University of Osaka, Osaka, 565-0871, Japan.
Hiroyuki NakamuraDepartment of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-8640, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although recent studies have reported the association between toxins produced by certain gut microbiota and elevated blood pressure, the relationship between oral frailty (OF) and gut microbiota has rarely been investigated. The purpose of this study was to epidemiologically investigate the relationship between the combination of OF and specific gut microbiota on hypertension in the residents of Shika Town, Ishikawa Prefecture, Japan. A total of 322 residents aged ⩾ 50 years in Shika Town agreed to participate and met the criteria. The OF was evaluated difficulty in chewing and swallowing, oral dryness, number of remaining teeth, and frequency of tooth brushing. Blood pressure was measured using an automatic digital blood pressure meter. Next-generation sequencing was used to analyze the gut microbiota. A two-way analysis of covariance revealed a significant interaction between the two OF groups and the two hypertension groups on Megamonas. The binomial logistic regression analysis stratified by OF revealed a positive correlation between Megamonas and hypertension (OR 1.317; P = 0.023). This cross-sectional epidemiological study of the local residents revealed that the abundance of Megamonas in the OF group was significantly higher in the hypertension group than in the normotension group; however, no such relationship was observed in the non-OF group.

Indexed as

gut microbiotahypertensionMegamonasoral healthregression analysis

Identifiers

PMID41454073

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.