Evidence map›Paper›PMID 41454137›Full record

ArticleStem cell reviews and reports2026

Complosome Activation after Myocardial Infarction in a Murine Model of Permanent LAD Ligation.

Janina Ratajczak, Ahmed Abdel-Latif, Gabriela Schneider, Tahra Luther, Rajesh Chaudhary, Parisa Shabani, Rachel Lopez, Afnan Alzamrooni, Anand Prakash Singh, Hafsa Jama and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reviews and reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Janina Ratajczak *Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street, Rm. 107, Louisville, KY, 40202, USA.
Ahmed Abdel-Latif *North Campus Research Complex (NCRC), University of Michigan Medicine, University of Michigan, Building 20, Floor 2, 207 W, Ann Arbor, MI, 48105, USA.
Gabriela SchneiderStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street, Rm. 107, Louisville, KY, 40202, USA.
Tahra LutherNorth Campus Research Complex (NCRC), University of Michigan Medicine, University of Michigan, Building 20, Floor 2, 207 W, Ann Arbor, MI, 48105, USA.
Rajesh ChaudharyNorth Campus Research Complex (NCRC), University of Michigan Medicine, University of Michigan, Building 20, Floor 2, 207 W, Ann Arbor, MI, 48105, USA.
Parisa ShabaniNorth Campus Research Complex (NCRC), University of Michigan Medicine, University of Michigan, Building 20, Floor 2, 207 W, Ann Arbor, MI, 48105, USA.
Rachel LopezNorth Campus Research Complex (NCRC), University of Michigan Medicine, University of Michigan, Building 20, Floor 2, 207 W, Ann Arbor, MI, 48105, USA.
Afnan AlzamrooniNorth Campus Research Complex (NCRC), University of Michigan Medicine, University of Michigan, Building 20, Floor 2, 207 W, Ann Arbor, MI, 48105, USA.
Anand Prakash SinghNorth Campus Research Complex (NCRC), University of Michigan Medicine, University of Michigan, Building 20, Floor 2, 207 W, Ann Arbor, MI, 48105, USA.
Hafsa JamaStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street, Rm. 107, Louisville, KY, 40202, USA.
Sham S KakarStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street, Rm. 107, Louisville, KY, 40202, USA.
Magdalena KuciaCenter for Preclinical Studies and Technology, Department of Regenerative Medicine, Warsaw Medical University, Warsaw, Poland.
Mariusz RatajczakStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street, Rm. 107, Louisville, KY, 40202, USA. mzrata01@louisville.edu.

Funding

Polish National Center Fundation OPUS grant UMO-2021/41/B/NZ3/01589, and OPUS grant UMO-2022/45/B/NZ6/00475Polish National Science Center Fundation OPUS grant UMO- 2022/45/B/NZ3/00476 to MK
6 · The paper itself

Abstract

It has been widely accepted for many years that the essential components of the complement cascade (ComC), including C3 and C5 proteins, are produced solely in the liver and released into circulation after synthesis. However, recent evidence shows that complement components are also expressed in other cell types, including human cardiomyocytes. Moreover, a new regulatory loop was identified in lymphocytes that regulates immune responses and metabolism, named the "Complosome." Following this significant discovery, the Complosome has been shown to play a role in the trafficking and metabolism of hematopoietic stem/progenitor cells (HSPCs) and is expressed in several types of bone marrow (BM) resident stem cells. ComC has been studied in various models of tissue and organ injury and regeneration. However, most of these studies did not distinguish between the role of systemic, liver-derived circulating complement in the blood and the complement expressed as a "Complosome" inside cells. Since Complosome is expressed in several types of stem cells that could influence the clinical outcome of myocardial infarction (MI), this distinction is important because intracellular components of the ComC may have beneficial roles in cell survival, growth, differentiation, and trafficking of stem and progenitor cells. We report herein the systemic activation of the Complosome in the heart and hematopoietic tissues in a murine model of myocardial infarction (MI).

Indexed as

Myocardial InfarctionAnimalsComplement ActivationComplement C3Complement C5Disease Models, AnimalHematopoietic Stem CellsHumansLigationMiceMice, Inbred C57BLComplement C3Complement C5Complement cascadeComplosomeMyocardial infarctionNlrp3 ingflammasome

Identifiers

PMID41454137
PMCPMC12858575

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.