Evidence map›Paper›PMID 41454207›Full record

SynthesisBiological trace element research2026

Systematic Review and Meta-Analysis on Heavy Metals and Trace Elements in Mild Cognitive Impairment.

Yaxin Dong, Lu Ren, TianRan Tang, Xinyi Zhang, Dan Han, Yingyi Luo, Liqiang Wang, Zonghui Cui, Sheng Ji, Jianheng Zheng and 1 more

Abstract readSystematic ReviewMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yaxin Dong *Shanghai University of Medicine & Health Sciences, No. 279, Zhouzhu Highway, Pudong New Area, Shanghai, 201318, China.
Lu Ren *Shanghai University of Medicine & Health Sciences, No. 279, Zhouzhu Highway, Pudong New Area, Shanghai, 201318, China.
TianRan TangMeteorological Bureau of Guizhou Province, Guizhou, 550002, China.
Xinyi ZhangShanghai University of Medicine & Health Sciences, No. 279, Zhouzhu Highway, Pudong New Area, Shanghai, 201318, China.
Dan HanShanghai University of Medicine & Health Sciences, No. 279, Zhouzhu Highway, Pudong New Area, Shanghai, 201318, China.
Yingyi LuoShanghai University of Medicine & Health Sciences, No. 279, Zhouzhu Highway, Pudong New Area, Shanghai, 201318, China.
Liqiang WangShanghai University of Medicine & Health Sciences, No. 279, Zhouzhu Highway, Pudong New Area, Shanghai, 201318, China.
Zonghui CuiPutuo District Center for Disease Control and Prevention, No. 1628, Danba Road, Putuo District, Shanghai, 200333, China.
Sheng JiShanghai University of Medicine & Health Sciences, No. 279, Zhouzhu Highway, Pudong New Area, Shanghai, 201318, China.
Jianheng ZhengNutrilite Health Institute, No. 6, Lane 720, Cailun Road, Pudong New Area, Shanghai, 201203, China. jennie.zheng@amway.com.
Ying QingShanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, No. 1600, Zhouyuan Road, Pudong New Area, Shanghai, 201300, China. qingy@sumhs.edu.cn.

Funding

the Shanghai Chenguang Program 21CGA70the Shanghai Sailing Program 21YF1418500the three-year action plan for strengthening the construction of the public health system in Shanghai GWVI-11.2-YQ12
6 · The paper itself

Abstract

Mild cognitive impairment (MCI) represents a prodromal stage of various neurodegenerative diseases. However, heterogeneity persists regarding heavy metal and trace element levels in MCI patients. PubMed, Web of Science, and Chinese academic databases were systematically searched from 2000 to the present, and 43 case-control/cross-sectional studies on the levels of heavy metals and trace elements in MCI and healthy controls were included, and the standardized mean difference (SMD) of 12 elements (Al, As, Cd, Pb, Cu, Se, Zn, etc.) was evaluated by using a random-effects model. A total of 16,743 samples were included. Al (SMD: 0.73, 95%CI: 0.31-1.14), As (SMD: 0.19, 95%CI: 0.03-0.35), Cd (SMD: 0.91, 95%CI: 0.43-1.38), Cu (SMD: 0.69, 95%CI. 0.27-1.10), Pb (SMD: 0.77, 95%CI: 0.30-1.24) were significantly elevated in the MCI patients, while Se (SMD: -0.28, 95%CI: -0.56-0.01) and Zn (SMD: -0.77, 95%CI: -1.22-0.33) were significantly lower. No statistical differences were observed for the remaining elements (Fe, Mg, etc.). Levels of specific heavy metals and trace elements in MCI patients differ from those in healthy controls. Monitoring and modulating these element levels may provide novel targets for early intervention strategies.

Indexed as

Cognitive DysfunctionMetals, HeavyTrace ElementsHumansMetals, HeavyTrace ElementsEarly interventionHeavy metalsMeta-analysisMild cognitive impairmentTrace elements

Identifiers

PMID41454207

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.