ArticleThe international journal of cardiovascular imaging2026
A deep learning methodology for fully-automated quantification of calcific burden in high-resolution intravascular ultrasound images.
Article in The international journal of cardiovascular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Dual-domain radio-frequency signal and image joint modeling for coronary calcium detection in intravascular ultrasound.Medical & biological engineering & computing · 2026Article
- Artificial Intelligence-Based Automated Assessment of the Four-Chamber View in Fetal Cardiac Ultrasound Videos.Bioengineering (Basel, Switzerland) · 2026Article
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Authors and funding
15 authors.
Funding
Abstract
Quantification of the calcific burden is valuable in percutaneous coronary intervention (PCI) planning and in research to assess its changes after pharmacotherapies targeting plaque progression. In intravascular ultrasound (IVUS) images this analysis is currently performed manually and time consuming. To overcome these limitations, we introduce a deep-learning (DL) method for seamless detection of the calcific tissue. IVUS images from 197 vessels were analysed by an expert who identified the presence of calcium, and these estimations were used to train a DL model for fast detection of calcific deposits. The output of the model was tested in a set of 30 vessels against the estimations of the two experts. Comparison was performed at a frame-, lesion- and segment level. In total 26,211 frames were included in the training and 5,138 in the test set. The estimations of the DL method for the presence of calcium were similar to the experts (kappa 0.842 and 0.848, p < 0.001), while the correlation between the DL approach and the two experts for the arc of calcium (0.946 and 0.947, p < 0.001) and calcific area (0.745 and 0.706, p < 0.001) were high. Lesion- (0.971 and 0.990, p < 0.001) and segment-level analysis (0.980 and 0.981, p < 0.001) demonstrated a high correlation between the method and the two experts for calcific burden. The proposed DL method is able to accurately detect the calcific tissue and quantify its burden. These features render it useful in research and are expected to facilitate its application in the clinical workflows to guide PCI.
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Registered trials
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