ArticleBehavioral and brain functions : BBF2025
Correlation of prefrontal-based resting state functional connectivity with the degree of cognitive impairment in Alzheimer's disease: a functional near-infrared spectroscopy study.
Article in Behavioral and brain functions : BBF, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Functional Near-Infrared Spectroscopy in Hearing Loss: A Systematic Review of Cortical Responses in Distinct Clinical Populations.Brain sciences · 2026Review
- Multimodal non-invasive approaches for early Alzheimer's disease detection: a review of neuroelectrophysiological and neuroimaging techniques.Frontiers in psychiatry · 2026Review
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Authors and funding
10 authors.
Funding
Abstract
backgroundThis study aims to investigate the differences in neural network connectivity within the prefrontal cortex (PFC) among elderly individuals with normal cognition (NC), mild cognitive impairment (MCI), and Alzheimer's disease (AD) using functional near-infrared spectroscopy (fNIRS).
resultsSignificant differences in functional connectivity (FC) strength were observed between the NC, MCI, and AD groups in several Brodmann areas (BA) pairs, including BA46.L-BA45.R and BA9.L-BA1.L. The most pronounced FC strength differences between the NC and MCI groups occurred at the 2nd -minute mark in BA45.R, while differences between the MCI and AD groups peaked at the 5th-minute mark in BA1.L. Additionally, the NC and MCI groups displayed FC strength differences during the first 2 minutes and first 3 minutes, again with BA45.R being central. FC strength between BA46.L-BA45.R was negatively correlated with Neuropsychiatric Inventory and Clinical Dementia Rating scores.
conclusionsFC strength in the left dorsolateral PFC, where BA46.L and BA9.L are located, emerged as a key region for cortical dysfunction in cognitive impairment. Moreover, there were differences in FC across levels of cognitive impairment, and significant correlations between differences in FC strength in BA brain regions and cognitive level.
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Registered trials
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