Evidence map›Paper›PMID 41454926›Full record

ArticleCellular and molecular life sciences : CMLS2025

METTL4 regulates synaptic UCP2 N6-adenosine methylation to mediate pain hypersensitivity in female mice.

Yanqiong Wu, Yifan Luo, Qin Xiao, Xueqin Xu, Wenjiao Jin, Longhui Li, Cheng Liu, Zhigang He, Zhixiao Li, Juan Li and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yanqiong WuDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430070, China.
Yifan LuoInstitute of Anesthesiology & Pain, Departments of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Qin XiaoInstitute of Anesthesiology & Pain, Departments of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Xueqin XuInstitute of Anesthesiology & Pain, Departments of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Wenjiao JinInstitute of Anesthesiology & Pain, Departments of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Longhui LiInstitute of Anesthesiology & Pain, Departments of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Cheng LiuDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430070, China.
Zhigang HeDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430070, China.
Zhixiao LiDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430070, China.
Juan LiDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430070, China.
Xuesong YangDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430070, China.
Fan JiangDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430070, China.
Zeyong YangDepartment of Anesthesiology, International Peace Maternity and Child Health Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200030, China.
Daqing MaDivision of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK.
Changbin KeInstitute of Anesthesiology & Pain, Departments of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China. changbinke-iap@taihehospital.com.ORCID http://orcid.org/0000-0003-0316-6455
Hongbing XiangDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430070, China. xhbtj2004@163.com.

Funding

China National Funds for Distinguished Young Scientists 82501490National Natural Science Foundation of China 32250018Natural Science Foundation of Hubei Province JCZRQT202500023Natural Science Foundation of Hubei Province JCZRYB202500348
6 · The paper itself

Abstract

Epitranscriptomics modifications play an important role in sex-dependent biological phenomena. N6-adenosine methylation (m6A), the most prevalent epitranscriptomics modification in eukaryotic mRNA, participates in regulating various sex-specific physiological processes. Here, we generated METTL4 knockout mice lacking methyltransferase-like 4, which mediates m6A. Behavioral analyses revealed that only female METTL4

Indexed as

AdenosineMethyltransferasesPainSynapsesUncoupling Protein 2AnimalsFemaleMaleMethylationMiceMice, Inbred C57BLMice, KnockoutMitochondriaSynaptic TransmissionAdenosineMethyltransferasesN-methyladenosineUncoupling Protein 2M6AMETTL4Mitochondrial metabolismPain hypersensitivitySexual dimorphismSynaptic transmissionUCP2

Identifiers

PMID41454926
PMCPMC12799839

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.