Evidence map›Paper›PMID 41455679›Full record

ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2026

The therapeutic pipeline in migraine: What does the future hold?

Mohammed Gamal-Eltrabily, Ana Belen Salinas-Abarca, Marcela Romero-Reyes, Simon Akerman

Abstract readReview
In one paragraph

Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The evolving landscape of primary headache therapy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mohammed Gamal-EltrabilyDepartment of Neural and Pain Sciences, University of Maryland Baltimore, Baltimore, MD 21201, USA; Center to Advance Chronic Pain Research, University of Maryland Baltimore, Baltimore, MD 21201, USA.
Ana Belen Salinas-AbarcaDepartment of Neural and Pain Sciences, University of Maryland Baltimore, Baltimore, MD 21201, USA; Center to Advance Chronic Pain Research, University of Maryland Baltimore, Baltimore, MD 21201, USA.
Marcela Romero-ReyesDepartment of Neural and Pain Sciences, University of Maryland Baltimore, Baltimore, MD 21201, USA; Center to Advance Chronic Pain Research, University of Maryland Baltimore, Baltimore, MD 21201, USA.
Simon AkermanDepartment of Neural and Pain Sciences, University of Maryland Baltimore, Baltimore, MD 21201, USA; Center to Advance Chronic Pain Research, University of Maryland Baltimore, Baltimore, MD 21201, USA. Electronic address: sakerman@umaryland.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Migraine is one of the leading causes of disability globally. Despite advances in the available pharmacological options for its management, many patients still show a lack of response to these current therapeutics. As a consequence, it is important to explore new targets for the management of migraine and related headache disorders. In this review, we discuss evidence related to various novel targets that are in different stages of development as part of the current therapeutic pipeline in migraine management. These include recent studies that report the role of specific ion channels in migraine pathophysiology, including ATP-sensitive potassium channels (K

Indexed as

Ion ChannelsMigraine DisordersAnimalsHumansOxytocinIon ChannelsOxytocinIon channelsNovel targetsOrexinOxytocinProlactinTRPM

Identifiers

PMID41455679
PMCPMC12996793

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.