ArticleCommunications biology2025
Tumor-secreted factors induce aberrant accumulation of vitamin A-enriched lipid droplets in the liver.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Longitudinal live-cell chemical imaging using coherent Raman scattering microscopy.The Analyst · 2026Review
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Authors and funding
10 authors.
Funding
Abstract
Cancer is increasingly recognized as a systemic disease, extending beyond local alterations to systemic alterations in distant organs through the release of various factors that promote tumor progression and metastasis. Here, we applied hyperspectral stimulated Raman scattering (hSRS) microscopy to study metabolic alterations in the liver driven by distant tumors, revealing unprecedented accumulation of vitamin A-enriched lipid droplets. Quantitative spectral analysis uncovered increased unsaturation levels and abnormal vitamin A ester. Notably, inhibition of secretory pathways in remote tumors effectively abrogated these metabolic alterations, with FABP5 in tumor-derived extracellular vesicles identified as a key mediator. These findings uncover a unique aspect of cancer progression mechanisms, implicating tumor-driven systemic lipid metabolic remodeling and vitamin A dysregulation in metastatic progression and therapeutic response.
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Registered trials
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