Evidence map›Paper›PMID 41456275›Full record

ArticleCell reports2026

Adult leptomeningeal vestigial neural crest-derived multipotent cells promote vascular repair after stroke.

Yoshihiko Nakamura, Takafumi Nakano, Lluis Alzamora-Llull, Ji-Hyun Park, Masayoshi Tanaka, Ester Licastro, Damian Panas, Shin Ishikane, Dong-Bin Back, Gen Hamanaka and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Yoshihiko NakamuraNeuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA; Department of Emergency and Critical Care Medicine, Fukuoka University Hospital, Fukuoka 814-0180, Japan.
Takafumi NakanoNeuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA; Department of Pharmaceutical and Healthcare Management, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
Lluis Alzamora-LlullNeuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Ji-Hyun ParkNeuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Masayoshi TanakaNeuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Ester LicastroNeuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Damian PanasInternational Centre for Translational Eye Research, Skierniewicka 10A, Warsaw 01-230, Poland; Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw 01-224, Poland.
Shin IshikaneNeuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Dong-Bin BackNeuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Gen HamanakaNeuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Wenlu LiNeuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Elga EspositoNeuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Yi ZhengNeuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Bum Ju AhnNeuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Violeta Durán-LaforetNeuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Rakhi DesaiNeuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Ikbal SencanOptics Division, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Klaus Van LeyenNeuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Sava SakadžićOptics Division, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Evan Y SnyderSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address: esnyder@sbp.edu.
Marcin TabakaInternational Centre for Translational Eye Research, Skierniewicka 10A, Warsaw 01-230, Poland; Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw 01-224, Poland. Electronic address: mtabaka@ichf.edu.pl.
Kazuhide HayakawaNeuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA. Electronic address: khayakawa1@mgh.harvard.edu.

Funding

Investigating the Microvascular Mechanisms of O2 Supply-Demand Mismatch in Small Vessel Disease using Novel High-Resolution Optical ImagingR01NS115401 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI AYATA, CENK, SAKADZIC, SAVA · 2020 to 2024
$3.5M
The effect of circadian rhythm disruptions on the angiogenic response to hypoperfusion in the AD brainR01AG081841 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Ken Arai, Eng H. Lo · 2023 to 2026
$3.0M
Meningeal Stem Cell Signals for Improving Sensorimotor and Cognitive Outcomes After StrokeR01NS115968 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI HAYAKAWA, KAZUHIDE, LO, ENG H. · 2020 to 2024
$2.0M
Two-photon Imaging of Oxygen and Blood Flow in Retinal and Cerebral VasculatureR01NS121095 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Sava Sakadzic, Mahnaz Shahidi · 2024 to 2026
$1.3M
NIA NIH HHS R01 AG081841NINDS NIH HHS R01 NS115401NINDS NIH HHS R01 NS115968NINDS NIH HHS R01 NS121095
6 · The paper itself

Abstract

The neural crest (NC) is a transient embryonic structure composed of highly migratory multipotent stem cells that generate diverse cell types and orchestrate early neurovascular patterning. It has long been assumed that NC cells are exhausted after development once their progeny fully differentiate. However, through NC lineage tracing, single-cell and spatial transcriptomics, interactome modeling, and in vivo imaging, we identified a population of NC-derived multipotent (not lineage-restricted) cells persisting within the adult mouse leptomeninges. Following ischemic stroke, loss- and gain-of-function analyses revealed that these cells are reactivated and recruited toward injured vascular endothelium via SDF1α-CXCR4 signaling; undergo stromal cell transition within the perivascular niche, regulated by β-catenin and STAT3 pathways; and restore vascular integrity through pleiotrophin-mediated signaling. These findings suggest that the adult leptomeninges harbor a vestigial reservoir of NC-derived multipotent cells-once central to embryogenesis and vasculogenesis-that can be re-invoked to promote neurovascular repair after cerebral injury.

Indexed as

MeningesMultipotent Stem CellsNeural CrestStrokeAnimalsbeta CateninCarrier ProteinsChemokine CXCL12CytokinesMaleMiceMice, Inbred C57BLNeovascularization, PhysiologicReceptors, CXCR4Signal TransductionSTAT3 Transcription Factorbeta CateninCarrier ProteinsChemokine CXCL12CytokinespleiotrophinReceptors, CXCR4STAT3 Transcription Factoradult leptomeningesblood-brain barrier restorationCD271CP: neuroscienceCP: stem cell researchCXCR4neural crestNGF receptorpleiotrophinPLP-1SDF1αSTAT3stroke repairβ-catenin

Identifiers

PMID41456275
PMCPMC12869227

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.