Evidence map›Paper›PMID 41456342›Full record

Trial reportJournal of the American Geriatrics Society2026

Efficacy of a Multicomponent Intervention for Frailty or Physical Function in Prefrail or Frail Older Adults: FRAILMERIT Multicenter Clinical Trial.

Adriana Abizanda Saro, Rafael García Molina, Rubén Alcantud Córcoles, Manuel Maestre Moreno, Raúl Sánchez Uceda, Ignacio Morón Merchante, Antonio Aragonés Jiménez, María Dolores González Céspedes, Pilar Montero Alía, Marta Simarro Rueda and 14 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Geriatrics Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05002439 (Multicenter Randomized Clinical Trial to Analyze the Efficacy of a Spanish Healthcare ministRy Based In InTervention to Reduce Frailty Status in Prefrail Older Adults), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05002439 narecruitingnot on this map

Multicenter Randomized Clinical Trial to Analyze the Efficacy of a Spanish Healthcare ministRy Based In InTervention to Reduce Frailty Status in Prefrail Older Adults (FRAILMERIT)

TypeinterventionalSponsorComplejo Hospitalario Universitario de AlbaceteRan2020 to 2025Enrolled273ConditionsFrailty, Aged, ExerciseArmsMulticomponent physical exercise program and a nutritional intervention
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Adriana Abizanda SaroUnitat de Suport a la Recerca, Área Metropolitana Nort, Institut Catalá de la Salut, Barcelona, Spain.
Rafael García MolinaDepartment of Geriatrics, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.ORCID 0000-0003-3498-1049
Rubén Alcantud CórcolesDepartment of Geriatrics, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.ORCID 0000-0002-5773-0835
Manuel Maestre MorenoLa Carlota Primary Care Center, Córdoba, Spain.
Raúl Sánchez UcedaAlbacete Zona 4 Primary Care Center, Gerencia de Atención Integrada de Albacete, Albacete, Spain.
Ignacio Morón MerchanteGoya Universitary Primary Care Center, Madrid, Spain.
Antonio Aragonés JiménezEl Sauzal Primary Care Center, Tacoronte, Spain.
María Dolores González CéspedesHellín 2 Primary Care Center, Hellín, Spain.
Pilar Montero AlíaUnitat de Suport a la Recerca, Área Metropolitana Nort, Institut Catalá de la Salut, Barcelona, Spain.
Marta Simarro RuedaAlbacete Zona 4 Primary Care Center, Gerencia de Atención Integrada de Albacete, Albacete, Spain.
Luis Torres AntónAlbacete Zona 8 Primary Care Center, Albacete, Spain.
Pilar Martínez GarcíaHellín 2 Primary Care Center, Hellín, Spain.
Humberto Soriano FernándezHellín 1 Primary Care Center, Hellín, Spain.
Marta Córcoles GarcíaAlbacete Zona 5 Primary Care Center, Albacete, Spain.
Ángel Moises Reyes AbreuEl Sauzal Primary Care Center, Tacoronte, Spain.
María Nuria Morcillo GonzálezGoya Universitary Primary Care Center, Madrid, Spain.
Elena García PáezLa Carlota Primary Care Center, Córdoba, Spain.
Beatriz Rodríguez SánchezUniversidad Complutense de Madrid, Madrid, Spain.
Marta Sáez BlesaCIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.
Elisa Belén Cortés ZamoraEscuela de Enfermería de la Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain.ORCID 0000-0001-8876-8345
Fernando Andrés PretelInstituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Toledo, Spain.
Almudena Avendaño CéspedesDepartment of Geriatrics, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.ORCID 0000-0003-3193-2276
FRAILMERIT Study Group
Pedro AbizandaDepartment of Geriatrics, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.ORCID 0000-0002-4707-2963

Funding

Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable CB16/10/00408Instituto de Salud Carlos III PI19/00962
6 · The paper itself

Abstract

objectivesFrailty is a common condition in community-dwelling older adults with high health and socioeconomic implications. However, primary care-led randomized trials have been scarcely tested.

designMulticenter cluster randomized clinical trial. SETTING AND

participantsTwo hundred and seventy-three community-dwelling older adults recruited from 12 Spanish primary care centers. INCLUSION CRITERIA: independence in basic activities of daily living and either prefrailty/frailty using the frailty phenotype or gait speed < 0.8 m/s.

methodsParticipants were randomized 1:1 by clusters to the intervention or the control group, each cluster being a different primary care center.

interventionPhysical exercise program, nutritional recommendations, and frailty training to primary care professionals. Interventions were conducted based on the guidelines of the "Consensus document on the prevention of frailty in older adults," updated in 2022, from the Spanish Health Ministry. CONTROL: Usual care. MAIN OUTCOME: Improvement in one category of the frailty phenotype or one point in the Short Physical Performance Battery (SPPB) at 12 and 32 weeks. under Intention-to-treat analysis was conducted.

resultsMean age 78.1 years, 68.4% female. 25.7% were frail and 74.3% prefrail or with a gait speed lower than 0.8 m/s. The percentage of participants improving the main outcome at week 12 for the intervention and control groups were 70.4% and 49.5%, respectively, absolute risk reduction (ARR) 20.9% (95% confidence interval [CI] 7.3%-34.5%; p < 0.01; n = 191), number needed to treat (NNT) 4.8 (95% CI 2.9-13.6). At 32 weeks of follow-up 81.7% and 51.9% of the intervention and control group improved, respectively, ARR 29.8% (95% CI 13.8%-45.7%; p < 0.001; n = 134), NNT 3.4 (95% CI 2.2-7.2). CONCLUSIONS AND IMPLICATIONS: A primary care-led intervention consisting of a physical exercise program, nutritional recommendations, and training in frailty was feasible and effective for improving frailty status or physical function in community-dwelling older adults with prefrailty or frailty.

trial registrationclinicaltrial.gov: NCT05002439 (18/JUN/2021).

Indexed as

Exercise TherapyFrail ElderlyFrailtyActivities of Daily LivingAgedAged, 80 and overFemaleGeriatric AssessmentHumansIndependent LivingMalePhysical Functional PerformancePrimary Health CareSpainexercisefrailtynutritionolder adultsphysical functionprimary carerandomized clinical trial

Identifiers

PMID41456342
PMCPMC12968357

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.