ReviewCNS neuroscience & therapeutics2025
Mitochondria-Associated Endoplasmic Reticulum Membranes as Potential Therapeutic Targets in Epilepsy.
Review in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Potential Role of Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) Abnormalities in Epileptogenesis: Multimodal Mechanisms and Therapeutic Targets.Molecular neurobiology · 2026Review
- Intranasal Biodegradable Nanomedicine for Epilepsy Management: Targeting the Brain Beyond the Blood-Brain Barrier.International journal of nanomedicine · 2026Review
- The Versatile Roles of Exosomes in Neurodegenerative Disorders: From Pathological Mechanism and Diagnostic Biomarkers to Therapeutic Application.Drug design, development and therapy · 2026Review
- Advanced neuroimaging in pediatric epilepsy surgery: state of the art and future perspectives.Neuroradiology · 2026Review
- Advanced neuroimaging in pediatric epilepsy surgery: state of the art and future perspectives.Neuroradiology · 2026Review
- Mitochondria-Associated Endoplasmic Reticulum Membranes as Potential Therapeutic Targets in Epilepsy.CNS neuroscience & therapeutics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundMitochondria-associated endoplasmic reticulum membranes (MAMs) are specialized regions in cells where the endoplasmic reticulum and mitochondria closely interact. MAMs are enriched with a variety of proteins that regulate key cellular processes. These processes include mitochondrial fission and fusion, autophagy, lipid metabolism, calcium homeostasis, and oxidative stress. Increasing evidence suggests that disruption of MAMs structure and alterations in associated protein expression patterns are closely related to the pathogenesis of epilepsy.
methodsThis review synthesizes and analyzes current literature to outline the structural and functional roles of key MAMs proteins. It further examines experimental and clinical evidence linking MAMs dysregulation to epileptogenesis and treatment responses.
resultsThe analysis confirms that MAMs serve as a central hub coordinating cellular homeostasis. Specific alterations in MAMs structure and protein expression are consistently associated with epilepsy models. These alterations directly impact neuronal excitability, synaptic function, and cell survival pathways involved in disease progression.
conclusionAddressing these structural and functional properties of MAMs may provide valuable insights for developing novel therapeutic strategies for epilepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.