Evidence map›Paper›PMID 41457989›Full record

ArticleAIDS (London, England)2026

Elevated sCD14 in cerebrospinal fluid: a surrogate marker for HIV-associated neurocognitive disorders in Brazil.

Carlos F Apoliano, Ana C S de Oliveira, Víctor  Folgosi, Gabriela S Prates, Maria R Gascon, José E Vidal, Jerusa Smid, Rosa M do N Marcusso, Augusto C Penalva, Youyang Tang and 3 more

Abstract readLetter
In one paragraph

Article in AIDS (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Carlos F ApolianoLaboratório de Investigação Médica LIM-56 - Divisão de Dermatologia, Faculdade de Medicina da Universidade de São Paulo.
Ana C S de OliveiraInstitute of Infectious Diseases "Emilio Ribas" (IIER) of São Paulo, São Paulo, Brazil.
Víctor  FolgosiLaboratório de Investigação Médica LIM-56 - Divisão de Dermatologia, Faculdade de Medicina da Universidade de São Paulo.
Gabriela S PratesLaboratório de Investigação Médica LIM-56 - Divisão de Dermatologia, Faculdade de Medicina da Universidade de São Paulo.
Maria R GasconInstitute of Infectious Diseases "Emilio Ribas" (IIER) of São Paulo, São Paulo, Brazil.
José E VidalInstitute of Infectious Diseases "Emilio Ribas" (IIER) of São Paulo, São Paulo, Brazil.
Jerusa SmidInstitute of Infectious Diseases "Emilio Ribas" (IIER) of São Paulo, São Paulo, Brazil.
Rosa M do N MarcussoInstitute of Infectious Diseases "Emilio Ribas" (IIER) of São Paulo, São Paulo, Brazil.
Augusto C PenalvaInstitute of Infectious Diseases "Emilio Ribas" (IIER) of São Paulo, São Paulo, Brazil.
Youyang TangUNC HIV Cure Center & Department of Biochemistry and Biophysics. University of North Carolina at Chapel Hill, NC, USA.
Guochun JiangUNC HIV Cure Center & Department of Biochemistry and Biophysics. University of North Carolina at Chapel Hill, NC, USA.
Camila M RomanoInstitute of Infectious Diseases "Emilio Ribas" (IIER) of São Paulo, São Paulo, Brazil.
Jorge CassebLaboratório de Investigação Médica LIM-56 - Divisão de Dermatologia, Faculdade de Medicina da Universidade de São Paulo.

Funding

Defining the HIV reservoir and latency mechanism in human brain myeloid cellsR01MH136852 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Guochun Jiang · 2024 to 2026
$2.3M
Characterize replication competent myeloid reservoirs in the central nervous systemR21MH128034 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JIANG, GUOCHUN · 2021 to 2022
$443k
Novel Epigenetic Marks for HIV Latency Entry and ReversalR21AI167709 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JIANG, GUOCHUN · 2023 to 2024
$428k
NIAID NIH HHS R21 AI167709NIMH NIH HHS R01 MH136852NIMH NIH HHS R21 MH128034
6 · The paper itself

Abstract

This study investigates cerebrospinal fluid (CSF) biomarkers associated with HIV-associated neurocognitive disorders (HAND) in people with HIV (PWH) in Brazil. Among 79 HIV-positive participants and 7 negative controls, elevated levels of inflammatory cytokines and soluble CD14 (sCD14) were found. The sCD14 showed promise as a diagnostic marker, and combined with other proinflammatory markers, may improve early detection and monitoring of HAND.

Indexed as

AIDS Dementia ComplexBiomarkersCerebrospinal FluidHIV InfectionsLipopolysaccharide ReceptorsNeurocognitive DisordersAdultBrazilCytokinesFemaleHumansMaleMiddle AgedBiomarkersCD14 protein, humanCytokinesLipopolysaccharide Receptors

Identifiers

PMID41457989
PMCPMC12935188

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.