Evidence map›Paper›PMID 41458154›Full record

ArticleFrontiers in cell and developmental biology2025

Molecular insights into Atorvastatin's role in delaying intervertebral disc degeneration.

Yupeng Li, Linghao Wang, Xingjie Wang, Kang Li, Qian Wang, Kai Gao, Cunxin Zhang, Chaoliang Lv

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yupeng LiDepartment of Spine Surgery, Jining NO.1 People's Hospital Affiliated to Shandong First Medical University and Shandong Academy of Medical Sciences, Jining, China.
Linghao WangDepartment of Spine Surgery, Jining NO.1 People's Hospital Affiliated to Shandong First Medical University and Shandong Academy of Medical Sciences, Jining, China.
Xingjie WangDepartment of Spine Surgery, Jining NO.1 People's Hospital Affiliated to Shandong First Medical University and Shandong Academy of Medical Sciences, Jining, China.
Kang LiDepartment of Spine Surgery, Jining NO.1 People's Hospital Affiliated to Shandong First Medical University and Shandong Academy of Medical Sciences, Jining, China.
Qian WangDepartment of Spine Surgery, Jining NO.1 People's Hospital Affiliated to Shandong First Medical University and Shandong Academy of Medical Sciences, Jining, China.
Kai GaoShandong Provincial Key Medical and Health Laboratory of Neuroinjury and Repair, Jining, China.
Cunxin ZhangDepartment of Spine Surgery, Jining NO.1 People's Hospital Affiliated to Shandong First Medical University and Shandong Academy of Medical Sciences, Jining, China.
Chaoliang LvDepartment of Spine Surgery, Jining NO.1 People's Hospital Affiliated to Shandong First Medical University and Shandong Academy of Medical Sciences, Jining, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study aimed to investigate the molecular mechanisms and effects of atorvastatin (Ator) in delaying intervertebral disc degeneration (IDD), with a particular focus on its role in modulating oxidative stress and apoptosis in nucleus pulposus cells (NPCs) via the Nrf2 signaling pathway. Methods: Results: Pretreatment with 10 μM atorvastatin significantly improved the survival rate of NPCs exposed to hydrogen peroxide (H Discussion: These findings indicate that atorvastatin alleviates H

Indexed as

atorvastatindisc degenerationNrf-2nucleus pulposus cellsoxidative stress

Identifiers

PMID41458154
PMCPMC12738912

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.