Evidence mapPaperPMID 41458162Full record

ReviewFrontiers in cell and developmental biology2025

Cartilage organoids: an emerging platform for novel osteoarthritis therapies.

Bimin Gao, Zecai Chen, Yufeng Long, Feng He, Donghao Gan, Weihong Yi, Guozhi Xiao, Jiangdong Ren, Lei Qin

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Saliva-based molecular diagnostics in oral squamous cell carcinoma (OSCC): a non-invasive frontier in oncology.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bimin Gao *Orthopaedic Innovation Laboratory, Shenzhen Nanshan People's Hospital, The Affiliated Nanshan Hospital of Shenzhen University, Shenzhen, Guangdong, China.
Zecai Chen *Orthopaedic Innovation Laboratory, Shenzhen Nanshan People's Hospital, The Affiliated Nanshan Hospital of Shenzhen University, Shenzhen, Guangdong, China.
Yufeng LongOrthopaedic Innovation Laboratory, Shenzhen Nanshan People's Hospital, The Affiliated Nanshan Hospital of Shenzhen University, Shenzhen, Guangdong, China.
Feng HeDepartment of Osteoarthropathy, Shenzhen Nanshan People's Hospital, Shenzhen, Guangdong, China.
Donghao GanDepartment of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, United States.
Weihong YiDepartment of Spine Surgery, Shenzhen Nanshan People's Hospital, Shenzhen, Guangdong, China.
Guozhi XiaoDepartment of Biochemistry, Homeostatic Medicine Institute, School of Medicine, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Jiangdong RenOrthopaedic Innovation Laboratory, Shenzhen Nanshan People's Hospital, The Affiliated Nanshan Hospital of Shenzhen University, Shenzhen, Guangdong, China.
Lei QinOrthopaedic Innovation Laboratory, Shenzhen Nanshan People's Hospital, The Affiliated Nanshan Hospital of Shenzhen University, Shenzhen, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is a chronic, multifactorial joint disorder characterized by the progressive degeneration and dysfunction of various joint tissues. Current treatments primarily focus on symptom management, offering limited success in halting cartilage degradation or repairing damaged tissues. Consequently, there is a pressing need for innovative therapeutic strategies aimed at cartilage regeneration and structural repair. Over the past 2 decades, cartilage organoids have emerged as a promising alternative for OA treatment. Due to their unique regenerative properties, cartilage organoids provide a versatile platform for various applications in OA research and therapy, including

Indexed as

cartilage organoidsdrug screeningin vitro modelsosteoarthritispersonalized therapies

Identifiers

PMID41458162
PMCPMC12741141

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.