ReviewCureus2025
HbA1c and the Severity of Acute Pancreatitis: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Impact of Diabetes Mellitus on Disease Severity and Mortality in Acute Pancreatitis: A Retrospective Single-Center Cohort Study.Journal of clinical medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHbA1c, a measure of long-term glycaemic control, has been identified as a potential prognostic risk factor for pancreatitis severity, yet there is a paucity of evidence on its association with pancreatitis outcomes in people with and without diabetes. We, therefore, conducted a systematic review and meta-analysis to assess the current body of evidence.
methodsArticles from January 1980 to March 2025 were screened using PubMed and the Excerpta Medica database (Embase). Randomised control trials (RCTs), cohort, and case-control studies were permitted for inclusion if they used an appropriate method for both acute pancreatitis (AP) diagnosis and severity classification. Quality assessment was performed using the Newcastle-Ottawa scale (NOS), and random effects models reporting pooled odds ratios (ORs) were estimated in our meta-analyses.
resultsOur search generated 2,270 results, from which two studies were eligible for inclusion with a total of 1,195 participants. Both studies were deemed to be at low risk of bias. The results of our meta-analyses demonstrated an increased odds of developing severe AP with increased HbA1c levels (OR = 2.14, 95% confidence interval (CI) 1.32-3.48). Elevated HbA1c levels were also found to increase the odds for developing local pancreatic complications (OR = 1.71, 95% CI 1.25-2.34) and systemic complications (pooled OR = 2.82, 95% CI 0.49-16.28).
conclusionsOur review suggests that elevated HbA1c levels may increase the likelihood of developing severe AP as well as local and systemic complications. The results of the review are limited due to the small number of included studies. We recommend that large multicentre cohort studies be conducted to further investigate this relationship.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.