Evidence map›Paper›PMID 41459155›Full record

ArticleFrontiers in cellular and infection microbiology2025

Gut and oral microbiome profiles in patients with obesity and ischemic heart disease.

Antonina Starodubova, Georgy Leonov, Nataliya Shaposhnikova, Yurgita Varaeva, Elena Livantsova, Denis Fotin, Tatiana Kirichenko, Mariam Bagheri Ekta, Yuliya Markina, Stanislav Koshechkin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Antonina StarodubovaDepartment of Cardiovascular Pathology and Diet Therapy, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russia.
Georgy LeonovDepartment of Cardiovascular Pathology and Diet Therapy, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russia.
Nataliya ShaposhnikovaDepartment of Cardiovascular Pathology and Diet Therapy, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russia.
Yurgita VaraevaDepartment of Cardiovascular Pathology and Diet Therapy, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russia.
Elena LivantsovaDepartment of Cardiovascular Pathology and Diet Therapy, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russia.
Denis FotinInstitute of Clinical Medicine, Pirogov Russian National Research Medical University, Moscow, Russia.
Tatiana KirichenkoPetrovsky National Research Center of Surgery, Moscow, Russia.
Mariam Bagheri EktaPetrovsky National Research Center of Surgery, Moscow, Russia.
Yuliya MarkinaPetrovsky National Research Center of Surgery, Moscow, Russia.
Stanislav KoshechkinNobias Technologies, Moscow, Russia.
Alexander OrekhovInstitute of General Pathology and Pathophysiology, Moscow, Russia.
Dmitry NikityukDepartment of Cardiovascular Pathology and Diet Therapy, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ischemic heart disease (IHD) and obesity are major contributors to global mortality. Both conditions are linked to systemic inflammation, dyslipidemia, and microbiota alterations. This study examines the relationship between the composition of the gut and oral microbiota, obesity, and IHD to gain insight into the interconnections between these factors. Methods: The study included 182 participants divided into four groups based on obesity and IHD status. Anthropometric and biochemical analyses were performed. Oral and gut microbiomes were analyzed using 16S rRNA sequencing. Results: Obesity and IHD were associated with distinct microbiota compositions. Obesity-IHD subjects showed elevated levels of gut Conclusions: This study demonstrates that obesity and IHD are linked to unique microbiota alterations. Microbial dysbiosis may contribute to the pathogenesis of these conditions and should be considered as a therapeutic target in the development of personalized treatment strategies of the obesity and associated cardiovascular complications.

Indexed as

BacteriaGastrointestinal MicrobiomeMicrobiotaMouthMyocardial IschemiaObesityAdultAgedDNA, BacterialDNA, RibosomalDysbiosisFemaleHumansMaleMiddle AgedRNA, Ribosomal, 16SDNA, BacterialDNA, RibosomalRNA, Ribosomal, 16S16S rRNA sequencinggut microbiomeIHDobesityoral microbiome

Identifiers

PMID41459155
PMCPMC12740868

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.