Evidence map›Paper›PMID 41459161›Full record

ArticleFrontiers in cellular and infection microbiology2025

Elucidation of neutrophils-mediated effect of MMP-2 on lung epithelial cells; implications for acute respiratory distress syndrome and severe dengue pathogenesis.

Rituraj Niranjan, Khashpatika Ganesh, Anupama Sunil, Vyshali Murugasamy, Pitchavel Vidhyapriya, Muthukumaravel Subramaniam, Ashwani Kumar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rituraj Niranjan *Immunology Laboratories, Division of Microbiology and Immunology, ICMR-Vector Control Research Centre, Puducherry, India.
Khashpatika Ganesh *Division of Molecular Biology and Immunology, ICMR- Vector Control Research Centre (ICMR-VCRC), Puducherry, India.
Anupama SunilImmunology Laboratories, Division of Microbiology and Immunology, ICMR-Vector Control Research Centre, Puducherry, India.
Vyshali MurugasamyImmunology Laboratories, Division of Microbiology and Immunology, ICMR-Vector Control Research Centre, Puducherry, India.
Pitchavel VidhyapriyaImmunology Laboratories, Division of Microbiology and Immunology, ICMR-Vector Control Research Centre, Puducherry, India.
Muthukumaravel SubramaniamDivision of Molecular Epidemiology, Indian Council of Medical Research (ICMR)-Vector Control Research Centre, Puducherry, India.
Ashwani KumarImmunology Laboratories, Division of Microbiology and Immunology, ICMR-Vector Control Research Centre, Puducherry, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue is a vector-borne viral fever that is spread by the bites of Aedes mosquitoes. Matrix metalloproteinases (MMPs) play a significant role in the beginning and development of dengue pathogenesis, but their precise functions with respect to neutrophil-associated lung pathology are not understood. In the present study, we, for the first time, report that

Indexed as

DengueEpithelial CellsMatrix Metalloproteinase 2NeutrophilsRespiratory Distress SyndromeSevere DengueA549 CellsAnimalsApoptosisDengue VirusDisease Models, AnimalHumansLungMiceMatrix Metalloproteinase 2acute respiratory distress syndromeAtorvastatindengue pathogenesisHL-60lung epithelial cellsMMP-2neutrophilsNS-1 Antigen

Identifiers

PMID41459161
PMCPMC12738819

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.