SynthesisFrontiers in microbiology2025
Probiotics in epilepsy treatment: a meta-analysis of efficacy and safety.
Synthesis in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Aging, the microbiota-gut-brain axis, and late-life epilepsy: a hypothesis-driven review.Frontiers in molecular neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Interest in probiotics for managing neurological disorders has grown recently. Methods: Eight public databases were searched for relevant randomized controlled trials (RCTs) published until May 31, 2025. Eligible studies were screened based on predefined inclusion and exclusion criteria. Basic characteristics and outcome data were extracted from the included studies, and the risk of bias was assessed. Meta-analyses, sensitivity analyses, and publication bias evaluations were performed using RevMan 5.3 software. The quality of evidence was rated using GRADEpro GDT. Results: Six RCTs involving 656 patients were included. Compared with the AED group, the probiotic combination group had significantly higher clinical efficacy rate (relative risk [RR] 1.16, 95% confidence interval [CI] 1.09 to 1.24, Conclusion: Probiotics improved seizure activity, relative power in certain EEG frequency bands, and intestinal barrier function without increasing the incidence of adverse reactions, supporting their feasibility as complementary treatment for epilepsy. Limited sample size and methodological necessitate further validation. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251079172, Identifier CRD420251079172.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.