ReviewFrontiers in immunology2025
Brain TRPV1 channel-mediated calcium influx: the immunomodulatory pathway of acupuncture in neuroinflammation.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Targeting TRPV1 channels: new perspectives on the mechanisms of analgesia for herpes zoster neuralgia and advances in therapeutic research.Frontiers in cellular and infection microbiology · 2026Pooled it
- Molecular mechanisms of perimenopausal cognitive impairment in a rat model: multi-omics integration reveals the Adgrl2-Camk2d-TRPV1 signaling axis mediating calcium homeostasis disruption and neuroinflammation.Frontiers in aging neuroscience · 2026Article
- Non-invasive neuroregulation techniques applied to patients with consciousness disorders: a narrative review.Frontiers in human neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroinflammation represents the central pathological process in neurological disorders. Effectively regulating neuroinflammation to restore immune homeostasis and alleviate neuronal damage has emerged as a critical strategy in the prevention and treatment of these diseases. In recent years, the role of acupuncture in neuroimmune regulation, along with its anti-inflammatory and analgesic effects, has attracted considerable attention. Its potential to modulate immune homeostasis and inflammatory responses through various targets and pathways has been gradually elucidated, offering new research directions for the regulation of neuroinflammation. A series of studies have emphasized that acupuncture has significant clinical applications by regulating the immunoinflammatory pathway mediated by the brain's TRPV1 channel. This discovery not only enhances the scientific understanding of the mechanisms underlying acupuncture but also offers new potential targets for the prevention and treatment of neuroinflammation-related diseases. The immunomodulatory properties of brain TRPV1 channels in inflammation associated with the nervous system have been emphasized. Furthermore, this study explores the immunomodulatory benefits of acupuncture in treating neuroinflammation, focusing on the potential mechanisms of TRPV1 channels at the brain level, as well as the criteria for selecting acupoints, intensity, frequency, and other relevant parameters in these studies. A deeper understanding of the neuroimmune regulatory mechanisms mediated by brain TRPV1 channels may offer new strategies and approaches for developing treatments or preventing neuropathological diseases.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.