Evidence map›Paper›PMID 41459558›Full record

ArticleFrontiers in neuroscience2025

Isogenic iPSC-derived

Suhjin Lee, Selvamani Vijayalingam, Elliott Klotz, Cass Dedert, Fenglian Xu, Govindaswamy Chinnadurai, Uthayashanker R Ezekiel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Delineating theInternational journal of molecular sciences · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Suhjin Lee *Department of Health Management and Policy, College of Public Health and Social Justice, Saint Louis University, St. Louis, MO, United States.
Selvamani Vijayalingam *Department of Genetics, Genome Engineering and Stem Cell Center (GESC@MGI), Washington University School of Medicine in St. Louis, St. Louis, MO, United States.
Elliott KlotzMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, United States.
Cass DedertDepartment of Biology, College of Arts and Sciences, Saint Louis University, St. Louis, MO, United States.
Fenglian XuDepartment of Biology, College of Arts and Sciences, Saint Louis University, St. Louis, MO, United States.
Govindaswamy ChinnaduraiDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Edward A. Doisy Research Center, St. Louis, MO, United States.
Uthayashanker R EzekielDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Edward A. Doisy Research Center, St. Louis, MO, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypotonia, ataxia, developmental delay, and tooth enamel defects syndrome (HADDTS) is a recently identified disorder linked to a heterozygous mutation in the C-terminal Binding Protein 1 (

Indexed as

CtBP1de novo mutationHADDTSisogenic cellstranscriptional repression

Identifiers

PMID41459558
PMCPMC12741082

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.