ReviewNucleic acids research2025
The CCR4-NOT complex: a multifaceted sensor of molecular signals instructing eukaryotic mRNA translation and stability.
Review in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- AR-V7 Utilizes a Noncanonical Nuclear Localization Signal to Sustain Androgen-Independent Nuclear Import and Signaling.bioRxiv : the preprint server for biology · 2026Article
- Selective decay of interferon mRNAs controls antiviral immunity and innate memory.Molecular cell · 2026Article
- Regulation of mRNA poly(A) tail length governs mammalian body plan formation in gastruloids.Nature communications · 2026Article
- Maintenance of phenotypic divergence in two sympatric monkeyflowers with weak reproductive isolation.bioRxiv : the preprint server for biology · 2026Article
- The ZFP36 Family as a Post-Transcriptional Immune Checkpoint in Immunity and Disease: Molecular Mechanisms and Functional Implications.Biomolecules · 2026Review
- Enhancing mRNA stability and translational potential through tailored modifications at the 3' end.RSC chemical biology · 2026Article
- The SPN-4 Rbfox RNA-binding protein selects maternal mRNAs for CCR4-NOT-dependent clearance in early Caenorhabditis elegans embryos.Development (Cambridge, England) · 2026Article
- Direct Mapping of CDK2 Substrates in Embryonic Stem Cells Uncovers an AP-Site Repair Mechanism via HMCES Phosphorylation.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The CCR4-NOT complex is a multi-subunit assembly found in all eukaryotic cells. Yet, its composition varies across organisms, with a universally conserved core enriched by lineage-specific subunits. Further, heterogeneity results from the occurrence of paralogous proteins, substoichiometric subunits, transient partners, and protein isoforms. Altogether, multiple CCR4-NOT complexes exist, and some even coexist within a single cell. The CCR4-NOT complex is an essential actor of gene expression through its roles in messenger RNA (mRNA) deadenylation, decay, and translation. Over time, support for the originally proposed role of the CCR4-NOT complex in transcription has been waning. Consistent with a role in post-transcriptional regulation, ribosomes appear to be major partners of the CCR4-NOT complex to coordinate translation and mRNA decay. Further, the CCR4-NOT complex is at the center of a network involving RNA-binding proteins and ubiquitin ligases, as well as factors of currently unknown function. Structural and functional analyses indicate that the CCR4-NOT complex integrates different levels of information present in mRNAs to control their stability and translation, thereby contributing to diverse functions including intricate processes such as human brain or pancreas development. It is thus not surprising that genetic alteration of this essential cellular machine, or impairment of its activity by pathogens, contributes to human diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.