Evidence map›Paper›PMID 41459804›Full record

Trial reportGut microbes2026

Effects of a slowly fermentable fiber mixture against the background of a high-protein diet on insulin sensitivity and metabolic health in individuals with overweight: a randomized, placebo-controlled trial.

Colin A J van Kalkeren, Thirza van Deuren, Miranda M J Coenjaerds, Gianluca Galazzo, David J M Barnett, John Penders, Bolette Hartmann, Jens J Holst, Emanuel E Canfora, Ellen E Blaak

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Colin A J van KalkerenDepartment of Human Biology, NUTRIM 'Institute of Nutrition and Translational Research in Metabolism', Maastricht University Medical Center+, Maastricht, The Netherlands.ORCID 0000-0003-1499-7190
Thirza van DeurenDepartment of Human Biology, NUTRIM 'Institute of Nutrition and Translational Research in Metabolism', Maastricht University Medical Center+, Maastricht, The Netherlands.ORCID 0000-0002-4839-9757
Miranda M J CoenjaerdsDepartment of Human Biology, NUTRIM 'Institute of Nutrition and Translational Research in Metabolism', Maastricht University Medical Center+, Maastricht, The Netherlands.ORCID 0000-0002-2663-7232
Gianluca GalazzoDepartment of Medical Microbiology, NUTRIM 'Institute of Nutrition and Translational Research in Metabolism', Maastricht University Medical Center+, Maastricht, The Netherlands.ORCID 0000-0001-9252-3447
David J M BarnettDepartment of Medical Microbiology, NUTRIM 'Institute of Nutrition and Translational Research in Metabolism', Maastricht University Medical Center+, Maastricht, The Netherlands.ORCID 0000-0003-1961-7206
John PendersDepartment of Medical Microbiology, NUTRIM 'Institute of Nutrition and Translational Research in Metabolism', Maastricht University Medical Center+, Maastricht, The Netherlands.ORCID 0000-0001-9146-5919
Bolette HartmannDepartment of Biomedical Sciences, NNF Center for Basic Metabolic Research, The Panum Institute, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8509-2036
Jens J HolstDepartment of Biomedical Sciences, NNF Center for Basic Metabolic Research, The Panum Institute, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-6853-3805
Emanuel E CanforaDepartment of Human Biology, NUTRIM 'Institute of Nutrition and Translational Research in Metabolism', Maastricht University Medical Center+, Maastricht, The Netherlands.ORCID 0000-0003-0267-1097
Ellen E BlaakDepartment of Human Biology, NUTRIM 'Institute of Nutrition and Translational Research in Metabolism', Maastricht University Medical Center+, Maastricht, The Netherlands.ORCID 0000-0002-2496-3464

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota ferments dietary fibers, producing short-chain fatty acids (SCFA). Enhanced SCFA production in the distal colon has been linked to improved cardiometabolic health. However, most fibers are fermented proximally, resulting in increased protein fermentation distally, producing metabolites putatively harmful to metabolic health. This 12-week randomized, placebo-controlled trial aimed to improve metabolic health through increasing distal SCFA production while inhibiting proteolytic fermentation using a fiber supplement that increased distal SCFA production

Indexed as

Dietary FiberDiet, High-ProteinInsulin ResistanceOverweightAdultDietary SupplementsFatty Acids, VolatileFemaleFermentationGastrointestinal MicrobiomeHumansMaleMiddle AgedObesitySolanum tuberosumDietary FiberFatty Acids, Volatilecardiometabolic healthDietary fiberfermentationinsulin resistancemicrobiome

Identifiers

PMID41459804
PMCPMC12758221

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.