Abnormal immunoglobulin expression and B-cell follicle organization in inborn errors of immunity/primary immunodeficiency.

Shachar Naor, Ginette Schiby, Etai Adam, Raz Somech, Yossef Molchanov, Iris Barshack, David B Lewis, Lianna Marks, Dita Gratzinger

Abstract read

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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shachar NaorDepartment of Pathology, Sheba Medical Center, Ramat Gan, Israel.ORCID http://orcid.org/0009-0001-7987-5015

Ginette SchibyDepartment of Pathology, Sheba Medical Center, Ramat Gan, Israel.ORCID http://orcid.org/0009-0005-6077-0239

Etai AdamDivision of Pediatric Hematology and Oncology, Sheba Medical Center, The Edmond and Lily Safra Children's Hospital, Ramat Gan, Israel.ORCID http://orcid.org/0009-0006-0746-8636

Raz SomechDivision of Pediatric Immunology, Sheba Medical Center, The Edmond and Lily Safra Children's Hospital, Ramat Gan, Israel.ORCID http://orcid.org/0000-0001-6648-9425

Yossef MolchanovDepartment of Pathology, Sheba Medical Center, Ramat Gan, Israel.ORCID http://orcid.org/0009-0000-4624-1801

Iris BarshackDepartment of Pathology, Sheba Medical Center, Ramat Gan, Israel.ORCID http://orcid.org/0000-0001-8216-8963

David B LewisDivision of Allergy, Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA.

Lianna MarksDivision of Pediatric Hematology, Oncology, Stem Cell Transplant and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-6036-3127

Dita GratzingerDepartment of Pathology, Stanford University School of Medicine, 300 Pasteur Dr. L235, Stanford, CA, 94305-5324, USA. ditag@stanford.edu.ORCID http://orcid.org/0000-0002-9182-8123

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with inborn errors of immunity/primary immunodeficiency (IEI/PID) frequently present with reactive lymphadenopathy which is biopsied to rule out lymphoma or infection. We asked whether reactive lymphoid tissue from an international cohort of 35 patients with IEI/PID contains diagnostic clues to the underlying immune dysfunction as compared to 13 control pediatric patients. To this end, we investigated abnormalities of B-cell follicle architecture and Immunoglobulin G (IgG) + class-switched (CS) versus IgM/IgD + non-IgG-CS Ig production. Abnormalities of B-cell follicles including absent or naked germinal centers (GCs) and/or increased T follicular helper(TFH) cells within GCs were seen in 45.7% (16/35) of IEI/PIDs and 15.4% (2/13) of controls (X

Indexed as

B-LymphocytesGerminal CenterImmunologic Deficiency SyndromesPrimary Immunodeficiency DiseasesAdolescentChildChild, PreschoolFemaleHumansImmunoglobulin Class SwitchingImmunoglobulin GInfantLymphadenopathyMaleImmunoglobulin GClass switch recombinationGerminal centerImmunodeficiencyInborn error of immunityLymph node

Identifiers

PMID41460331

DOI10.1016/j.ebiom.2023.104501

What Socratic holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.