Evidence map›Paper›PMID 41460356›Full record

ArticleJournal of molecular histology2025

Renoprotective effect of polyphenolic-rich extract of Phyllanthus niruri in streptozotocin-induced diabetic nephropathy via moderation of oxidative stress and inhibition of kidney injury.

Olakunle Bamikole Afolabi, Ayomide Gabriel Akinola, Aisha Kanoyinsola Raji, Olabisi Tajudeen Obafemi, Oluwaseun Ruth Olasehinde, Adejoke Oluyemi Olorunlagba, Oluwafemi Emmanuel Babatunde, Blessing Ariyo Obafemi, Olaposi Idowu Omotuyi, Omotade Ibidun Oloyede and 2 more

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Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Olakunle Bamikole AfolabiPhytomedicine and Toxicology Unit, Biochemistry Programme, Department of Chemical Sciences, College of Sciences, Afe-Babalola University, P.M.B 5454, Ado- Ekiti, Ekiti State, Nigeria.
Ayomide Gabriel AkinolaPhytomedicine and Toxicology Unit, Biochemistry Programme, Department of Chemical Sciences, College of Sciences, Afe-Babalola University, P.M.B 5454, Ado- Ekiti, Ekiti State, Nigeria.
Aisha Kanoyinsola RajiPhytomedicine and Toxicology Unit, Biochemistry Programme, Department of Chemical Sciences, College of Sciences, Afe-Babalola University, P.M.B 5454, Ado- Ekiti, Ekiti State, Nigeria.
Olabisi Tajudeen ObafemiDepartment of Life and Consumer Sciences, University of South Africa Florida Campus, Johannesburg, 1710, South Africa. oobafemi@abuad.edu.ng.
Oluwaseun Ruth OlasehindeDepartment of Medical Biochemistry, College of Medicine and Health Sciences, Afe Babalola University, P.M.B 5454, Ado-Ekiti, Ekiti State, Nigeria.
Adejoke Oluyemi OlorunlagbaDepartment of Biochemistry, Ekiti State University, P.M.B 5363, Ado-Ekiti, Ekiti State, Nigeria.
Oluwafemi Emmanuel BabatundeDepartment of Biochemistry, Hillside University of Science and Technology, Ikoro Road, Okeimesi-Ekiti, Ekiti State, Nigeria.
Blessing Ariyo ObafemiDepartment of Medical Biochemistry, College of Medicine and Health Sciences, Afe Babalola University, P.M.B 5454, Ado-Ekiti, Ekiti State, Nigeria.
Olaposi Idowu OmotuyiS.E Bogoro Center, Institute for Drug Research and Development, Afe Babalola University, P.M.B 5454, Ado-Ekiti, Ekiti State, Nigeria.
Omotade Ibidun OloyedeDepartment of Biochemistry, Ekiti State University, P.M.B 5363, Ado-Ekiti, Ekiti State, Nigeria.
Sogolo Lucky LebeloDepartment of Life and Consumer Sciences, University of South Africa Florida Campus, Johannesburg, 1710, South Africa.
Monde McMillan NtwasaDepartment of Life and Consumer Sciences, University of South Africa Florida Campus, Johannesburg, 1710, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies have underlined the relevance of plants as sources of medicament for diabetes mellitus its sequelae. This research sought to appraise the renal-protective effect of the polyphenolic-rich extract of Phylanthus niruri (PEPN) leaves in Wistar rats made diabetic with streptozotocin. Fifty-six rats were arbitrarily grouped into seven places (n = 8). Standard procedure was used to extract polyphenols from the leaves using 80% acetone. Experimental groups included normal control, diabetic untreated, as well as diabetic groups managed with 5/500 mg/kg bw glibenclamide/metformin and diabetic groups each treated with 50, 75, 100 and 125 mg/kg bw PEPN. The study lasted for 28 days. After treatment period, standard procedures were used to evaluate activities of antioxidant enzymes and kidney injury markers in the kidney, while levels of creatinine, urea and uric acid were measured in the serum. Findings show that treatment of diabetic rats with PEPN led to a significant (p < 0.05) lowering of serum uric acid, urea and creatinine when compared with diabetic control group. Similarly, the administration of PEPN led to a significant (p < 0.05) elevation of enzymatic functions of superoxide dismutase and catalase in the kidney, with a concomitant reduction in malondialdehyde. In addition, PEPN therapy in diabetic rats with PEPN significantly (p < 0.05) diminished mRNA levels of kidney injury marker 1 and neutrophil gelatinase-associated lipocalin in the kidney when compared to untreated diabetic rats. Therefore, it could be concluded that PEPN could confer renoprotection in diabetic rats by enhancing the antioxidant system and suppression of kidney injury marker genes.

Indexed as

Diabetes Mellitus, ExperimentalDiabetic NephropathiesOxidative StressPhyllanthusPlant ExtractsPolyphenolsProtective AgentsAnimalsAntioxidantsBiomarkersCatalaseCreatinineKidneyMalePlant LeavesRatsAntioxidantsBiomarkersCatalaseCreatininePlant ExtractsPolyphenolsProtective AgentsStreptozocinSuperoxide DismutaseUreaUric AcidDiabetes mellitusNephrotoxicityOxidative stressPhylanthus niruriStreptozotocin

Identifiers

PMID41460356

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.