Evidence map›Paper›PMID 41460367›Full record

ArticleMolecular biology reports2025

Genetic and epigenetic contribution of ABCG2 to gout susceptibility: a case-control study.

Denise Clavijo-Cornejo, Javier Fernández Torres, Mónica Santamaria-Olmedo, Yessica Zamudio-Cuevas, Karina Martínez-Flores, Alba Paulina Flores-López, Ambar López-Macay

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Denise Clavijo-CornejoRheumatology Laboratory, National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra, Tlalpan, CDMX, Mexico.ORCID http://orcid.org/0000-0002-6399-9865
Javier Fernández TorresSynovial Fluid Laboratory, National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra, Calzada México-Xochimilco n.289, Colonia Arenal de Guadalupe, Tlalpan, CDMX, 14389, Mexico.ORCID http://orcid.org/0000-0002-7271-2862
Mónica Santamaria-OlmedoGenetic Laboratory, National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra, Tlalpan, CDMX, Mexico.ORCID http://orcid.org/0000-0003-4100-9346
Yessica Zamudio-CuevasSynovial Fluid Laboratory, National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra, Calzada México-Xochimilco n.289, Colonia Arenal de Guadalupe, Tlalpan, CDMX, 14389, Mexico.ORCID http://orcid.org/0000-0003-1751-3454
Karina Martínez-FloresSynovial Fluid Laboratory, National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra, Calzada México-Xochimilco n.289, Colonia Arenal de Guadalupe, Tlalpan, CDMX, 14389, Mexico.ORCID http://orcid.org/0000-0003-0675-0227
Alba Paulina Flores-LópezNovartis, 220 E, Hanover Ave, Morris Plains, NJ, 07950, USA.ORCID http://orcid.org/0009-0003-4103-4370
Ambar López-MacaySynovial Fluid Laboratory, National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra, Calzada México-Xochimilco n.289, Colonia Arenal de Guadalupe, Tlalpan, CDMX, 14389, Mexico. alopezm@inr.gob.mx.ORCID http://orcid.org/0000-0002-2916-7424

Funding

Consejo Nacional de Ciencia y Tecnología, México SALUD‑2014‑1‑233886
6 · The paper itself

Abstract

backgroundGout is a disease characterized by joint pain due to an inflammatory response triggered by the precipitation of monosodium urate (MSU) crystals in joints. ATP-binding cassette subfamily G member 2 (ABCG2) is a protein involved in urate transport and in the protection of cells against drugs.

objectiveAnalyze the effect of the presence of the ABCG2 single nucleotide polymorphisms (SNPs) rs2231142 and rs72552713 through the analysis of ABCG2 promoter methylation and gene expression to assess their effect on the development of gout.

methodsThis is a case‒control study that included 560 subjects of Mexican origin. ABCG2 SNPs were analyzed from the DNA of peripheral blood. Expression and methylation analyses of ABCG2 were performed via RT‒qPCR.

resultsAfter adjustment by age, sex, age, Body mass index (BMI), serum uric acid (SUA), glucose, and Triglycerides (TG), significant differences were observed in the distribution of the rs2231142 genotype. In the codominant model, the homozygous TT genotype was associated with an increased risk of gout (OR = 34.99, 95% CI = 13.38-91.52; P < 0.0001). A negative correlation was found between the methylation percentage and gene expression in patients (r: -0.48, P < 0.01) and the percentage of promoter methylation of ABCG2 gene was greater (p < 0.05) in individuals with the GT genotype than in those with the GG genotype among the total participants.

conclusionChanges in the expression and methylation of the ABCG2 gene in patients with gout may be associated with the presence of SNPs such as rs2231142, which appears to have functional relevance in gout susceptibility in the Mexican population studied.

Indexed as

ATP Binding Cassette Transporter, Subfamily G, Member 2Epigenesis, GeneticGenetic Predisposition to DiseaseGoutNeoplasm ProteinsAdultAgedCase-Control StudiesDNA MethylationFemaleGenotypeHumansMaleMexicoMiddle AgedPolymorphism, Single NucleotideABCG2 protein, humanATP Binding Cassette Transporter, Subfamily G, Member 2Neoplasm ProteinsUric AcidABCG2DNA methylationGoutHyperuricemiaRs2231142

Identifiers

PMID41460367

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.