Evidence map›Paper›PMID 41461029›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Enhanced insulin signaling via circulating ATG7: A potential therapeutic strategy for diabetes.

Yi Guan, Yang Yu, Mengdi Fu, Hongde Xu, Eunyoung Lee, Hanfeng Wang, José María Moreno-Navarrete, Chengsi Deng, Yuheng Li, Kangjing Song and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Yi Guan *Clinical Translational Research Center, Shengjing Hospital, Health Sciences Institute, Key Laboratory of Medical Cell Biology, Ministry of Education, College of Basic Medical Science, Key Laboratory of Liaoning Province, Health Sciences Institute, China Medical University, Shenyang, Liaoning Province 110122, China.
Yang Yu *Clinical Translational Research Center, Shengjing Hospital, Health Sciences Institute, Key Laboratory of Medical Cell Biology, Ministry of Education, College of Basic Medical Science, Key Laboratory of Liaoning Province, Health Sciences Institute, China Medical University, Shenyang, Liaoning Province 110122, China.ORCID 0000-0002-2480-7306
Mengdi Fu *Clinical Translational Research Center, Shengjing Hospital, Health Sciences Institute, Key Laboratory of Medical Cell Biology, Ministry of Education, College of Basic Medical Science, Key Laboratory of Liaoning Province, Health Sciences Institute, China Medical University, Shenyang, Liaoning Province 110122, China.
Hongde Xu *Clinical Translational Research Center, Shengjing Hospital, Health Sciences Institute, Key Laboratory of Medical Cell Biology, Ministry of Education, College of Basic Medical Science, Key Laboratory of Liaoning Province, Health Sciences Institute, China Medical University, Shenyang, Liaoning Province 110122, China.
Eunyoung LeeDepartment of Medical Physiology, Graduate School of Medicine, Research Institute of Disaster Medicine, Chiba University, Chiba 260-0856, Japan.ORCID 0000-0003-3021-1127
Hanfeng WangClinical Translational Research Center, Shengjing Hospital, Health Sciences Institute, Key Laboratory of Medical Cell Biology, Ministry of Education, College of Basic Medical Science, Key Laboratory of Liaoning Province, Health Sciences Institute, China Medical University, Shenyang, Liaoning Province 110122, China.
José María Moreno-NavarreteInstitut d'Investigació Biomèdica de Girona, University of Girona, Girona 17071, Spain.
Chengsi DengClinical Translational Research Center, Shengjing Hospital, Health Sciences Institute, Key Laboratory of Medical Cell Biology, Ministry of Education, College of Basic Medical Science, Key Laboratory of Liaoning Province, Health Sciences Institute, China Medical University, Shenyang, Liaoning Province 110122, China.
Yuheng LiClinical Translational Research Center, Shengjing Hospital, Health Sciences Institute, Key Laboratory of Medical Cell Biology, Ministry of Education, College of Basic Medical Science, Key Laboratory of Liaoning Province, Health Sciences Institute, China Medical University, Shenyang, Liaoning Province 110122, China.
Kangjing SongClinical Translational Research Center, Shengjing Hospital, Health Sciences Institute, Key Laboratory of Medical Cell Biology, Ministry of Education, College of Basic Medical Science, Key Laboratory of Liaoning Province, Health Sciences Institute, China Medical University, Shenyang, Liaoning Province 110122, China.
Qiqiang GuoClinical Translational Research Center, Shengjing Hospital, Health Sciences Institute, Key Laboratory of Medical Cell Biology, Ministry of Education, College of Basic Medical Science, Key Laboratory of Liaoning Province, Health Sciences Institute, China Medical University, Shenyang, Liaoning Province 110122, China.ORCID 0000-0001-7905-7111
Xiaoyou JiangClinical Translational Research Center, Shengjing Hospital, Health Sciences Institute, Key Laboratory of Medical Cell Biology, Ministry of Education, College of Basic Medical Science, Key Laboratory of Liaoning Province, Health Sciences Institute, China Medical University, Shenyang, Liaoning Province 110122, China.ORCID 0009-0009-9339-9009
Xiaoyu SongClinical Translational Research Center, Shengjing Hospital, Health Sciences Institute, Key Laboratory of Medical Cell Biology, Ministry of Education, College of Basic Medical Science, Key Laboratory of Liaoning Province, Health Sciences Institute, China Medical University, Shenyang, Liaoning Province 110122, China.ORCID 0000-0002-6606-327X
Wendong GuoClinical Translational Research Center, Shengjing Hospital, Health Sciences Institute, Key Laboratory of Medical Cell Biology, Ministry of Education, College of Basic Medical Science, Key Laboratory of Liaoning Province, Health Sciences Institute, China Medical University, Shenyang, Liaoning Province 110122, China.
Yanling FengClinical Translational Research Center, Shengjing Hospital, Health Sciences Institute, Key Laboratory of Medical Cell Biology, Ministry of Education, College of Basic Medical Science, Key Laboratory of Liaoning Province, Health Sciences Institute, China Medical University, Shenyang, Liaoning Province 110122, China.ORCID 0000-0001-8742-177X
Fei YiClinical Translational Research Center, Shengjing Hospital, Health Sciences Institute, Key Laboratory of Medical Cell Biology, Ministry of Education, College of Basic Medical Science, Key Laboratory of Liaoning Province, Health Sciences Institute, China Medical University, Shenyang, Liaoning Province 110122, China.
Ning BaiClinical Translational Research Center, Shengjing Hospital, Health Sciences Institute, Key Laboratory of Medical Cell Biology, Ministry of Education, College of Basic Medical Science, Key Laboratory of Liaoning Province, Health Sciences Institute, China Medical University, Shenyang, Liaoning Province 110122, China.
Jiabin LiKey Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang, Liaoning Province 110122, China.
Jingyang ChenMedical Basic Experimental Teaching Centre, China Medical University, Shenyang, Liaoning Province 110122, China.
Wenjing ShenDepartment of Gynecology, The First Hospital of China Medical University, Shenyang, Liaoning Province 110001, China.
Wan YuDepartment of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province 110022, China.ORCID 0009-0006-2891-018X
Difei WangDepartment of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province 110022, China.ORCID 0000-0002-1118-658X
Siru HouCenter of Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province 110022, China.ORCID 0009-0002-0951-238X
Jichun TanCenter of Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province 110022, China.ORCID 0000-0002-6401-1919
José-Manuel Fernández-RealInstitut d'Investigació Biomèdica de Girona, University of Girona, Girona 17071, Spain.ORCID 0000-0002-7442-9323
Antonio Vidal-PuigMedical Research Council, Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 1TN, United Kingdom.ORCID 0000-0003-4220-9577
Liu CaoClinical Translational Research Center, Shengjing Hospital, Health Sciences Institute, Key Laboratory of Medical Cell Biology, Ministry of Education, College of Basic Medical Science, Key Laboratory of Liaoning Province, Health Sciences Institute, China Medical University, Shenyang, Liaoning Province 110122, China.ORCID 0000-0001-6471-1993

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes and insulin resistance (IR) remain major global health challenges, underscoring the need for novel therapeutic strategies. Here, we identify an autophagy-independent role of circulating autophagy-related gene 7 (ATG7) in metabolic regulation. Circulating ATG7 enhances insulin sensitivity and glucose homeostasis by directly interacting with IRS1 and modulating insulin signaling (IS) through liver-muscle crosstalk. Mechanistically, ATG7 binds to IRS1, promoting its activation and the propagation of downstream IS. Notably, we identify an ATG7-derived peptide (Aap2) that recapitulates ATG7's insulin-sensitizing effects and improves glycemic control in both Type 1 and Type 2 diabetic mouse models. These findings establish ATG7 as a key regulator of IS and suggest that targeting ATG7 may represent a promising therapeutic approach for IR and diabetes.

Indexed as

Autophagy-Related Protein 7Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2InsulinSignal TransductionAnimalsAutophagyDiabetes Mellitus, ExperimentalHumansInsulin Receptor Substrate ProteinsInsulin ResistanceLiverMaleMiceMice, Inbred C57BLAtg7 protein, mouseAutophagy-Related Protein 7InsulinInsulin Receptor Substrate ProteinsIrs1 protein, mouseATG7exosomesglucose homeostasisinsulin resistanceIRS1

Identifiers

PMID41461029
PMCPMC12773708

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.