Evidence map›Paper›PMID 41461362›Full record

ArticleOsteoarthritis and cartilage2026

Osteocyte-Intrinsic MMP13 exacerbates injury-induced temporomandibular joint osteoarthritis.

Cristal S Yee, Marianne Demirdji, Karsyn N Bailey, Alena D Larios, Christoforos Meliadis, Clarissa Aguirre Luna, Harrison B Taylor, Peggi M Angel, Sunil Kapila, Tamara Alliston

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cristal S YeeDepartment of Orthopaedic Surgery, University of California, San Francisco, CA, United States. Electronic address: cristal.yee@ucsf.edu.
Marianne DemirdjiDepartment of Orthopaedic Surgery, University of California, San Francisco, CA, United States. Electronic address: mdemirdji@gmail.com.
Karsyn N BaileyDepartment of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO, United States. Electronic address: karsyn.bailey@wustl.edu.
Alena D LariosDepartment of Orthopaedic Surgery, University of California, San Francisco, CA, United States. Electronic address: allie.larios@gmail.com.
Christoforos MeliadisDepartment of Orthopaedic Surgery, University of California, San Francisco, CA, United States. Electronic address: christoforos.meliadis@ucsf.edu.
Clarissa Aguirre LunaDepartment of Orthopaedic Surgery, University of California, San Francisco, CA, United States. Electronic address: clarissa.aguirreluna@ucsf.edu.
Harrison B TaylorDepartment of Pharmacology & Immunology, Proteomics Center, Medical University of South Caroline, Charleston, SC, United States. Electronic address: taylorha@musc.edu.
Peggi M AngelDepartment of Pharmacology & Immunology, Dermatology & Dermatologic Surgery, Medical University of South Carolina, Charleston, SC, United States. Electronic address: angelp@musc.edu.
Sunil KapilaSection of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, United States. Electronic address: skapila@dentistry.ucla.edu.
Tamara AllistonDepartment of Orthopaedic Surgery, University of California, San Francisco, CA, United States; National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, United States. Electronic address: tamara.alliston@nih.gov.

Funding

The mechanistic control of bone quality and joint crosstalk by osteocytesR01DE019284 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERNANDEZ, CHRISTOPHER JOHN · 2009 to 2024
$7.6M
Skeletal Biology and Biomechanics (SBB) CoreP30AR075055 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Wenhan Chang · 2019 to 2026
$7.1M
Bruker scimaX™ Magnetic Resonance Mass SpectrometerS10OD030212 · OD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ANGEL, PEGGI M · 2021 to 2021
$1.7M
MicroCT 100S10RR026475 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOHN, DAVID H. · 2010 to 2010
$381k
Interdisciplinary Clinical Advances and Research Excellence in TMDs (ICARE 4 TMDs) CollaborativeR34DE033595 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KAPILA, SUNIL D · 2023 to 2023
$312k
NCRR NIH HHS S10 RR026475NIAMS NIH HHS P30 AR075055NIDCR NIH HHS R01 DE019284NIDCR NIH HHS R34 DE033595NIH HHS S10 OD030212
6 · The paper itself

Abstract

objectiveCartilage in the knee and temporomandibular joint (TMJ) rely on subchondral bone for joint homeostasis, whereby osteoarthritis (OA) causes degeneration. In the knee, suppression of osteocytic perilacunocanalicular remodeling drives cartilage degeneration in a destabilization of the medial meniscus model of OA. Given the structural and functional differences between knee and TMJ osteochondral tissues, whether osteocytes also play a causal role in TMJOA remains to be determined. We hypothesize that subchondral bone osteocytes are required for TMJ homeostasis.

methodWe evaluated the role of osteocytic MMP13 in the TMJ using 16-week-old mixed FVB and C57BL/6 male mice with osteocyte-intrinsic loss of MMP13 (DMP1-cre

resultsUnlike baseline differences in knees of DMP1-cre

conclusionDespite different roles for osteocytic MMP13 in TMJ and knee, osteocytic MMP13 deficiency protects both joints from injury-dependent effects on subchondral bone.

Indexed as

Matrix Metalloproteinase 13OsteoarthritisOsteocytesTemporomandibular JointTemporomandibular Joint DisordersAnimalsCartilage, ArticularDisease Models, AnimalMaleMiceMice, Inbred C57BLOsteoarthritis, KneeMatrix Metalloproteinase 13Mmp13 protein, mouseMonosodium iodoacetateOsteoarthritisOsteocytePathogenesisPerilacuno canalicular remodelingTemporomandibular joint

Identifiers

PMID41461362
PMCPMC12912257

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.