Evidence map›Paper›PMID 41461616›Full record

SynthesisJournal of prevention (2022)2026

Sleep Disorders and Nonalcoholic Fatty Liver Disease: Evidence From Meta-Analysis and Mendelian Randomization.

Haibo Wang, Linyin Huang, Meng Yu, Shifang Qu, Yanqi Wang, Xu Cao, Yiwen Meng, Yongxia Gao, Bing Ding, Wei Bai and 1 more

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of prevention (2022), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haibo WangDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, 130021, Jilin, China.
Linyin HuangDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, 130021, Jilin, China.
Meng YuDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, 130021, Jilin, China.
Shifang QuDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, 130021, Jilin, China.
Yanqi WangDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, 130021, Jilin, China.
Xu CaoDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, 130021, Jilin, China.
Yiwen MengDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, 130021, Jilin, China.
Yongxia GaoDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, 130021, Jilin, China.
Bing DingDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, 130021, Jilin, China.
Wei BaiDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, 130021, Jilin, China.
Yan YaoDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, 130021, Jilin, China. yaoyan@jlu.edu.cn.ORCID http://orcid.org/0000-0002-1823-3684

Funding

Jilin Provincial Scientific and Technological Development Program 20240601018RC
6 · The paper itself

Abstract

Background Sleep disorders and Non-alcoholic Fatty Liver Disease (NAFLD) bare both highly prevalent globally. But the relationships between them remain unclear. So we aimed to explore the impact of sleep disorders on NAFLD risk. Methods Using a combination of meta-analysis and Mendelian Randomization (MR), we investigated the associations between three common sleep disorders and NAFLD, including insomnia, obstructive sleep apnea (OSA) and narcolepsy. For meta-analysis, we systematically searched PubMed, Web of Science and Embase up to July 3, 2024. Ultimately, 13 studies were included, encompassing a total of 537,497 participants. Subsequently, MR analyses were performed to explore the causal relationships between each of the three sleep disorders and NAFLD. Results The meta-analysis revealed that insomnia (OR = 1.40, 95% CI: 1.05-1.87), OSA (OR = 2.15, 95% CI: 1.47-3.13) and narcolepsy (OR = 1.38, 95% CI: 1.05-1.80) were all associated with an elevated NAFLD risk. Moreover, MR analysis indicated a causal relationship between OSA and NAFLD (OR = 1.19, 95% CI: 1.04-1.37, P = 0.042). However, the strong evidence of the causal relationships between narcolepsy or insomnia and NAFLD was not found. Conclusion In this study, meta-analysis results indicate a significant link between the three common sleep disorders (insomnia, OSA, narcolepsy) and increased NAFLD risk. MR analysis suggests a causal relationship between OSA and NAFLD. However, there's no sufficient evidence for causal links of both narcolepsy and insomnia with NAFLD.

Indexed as

Non-alcoholic Fatty Liver DiseaseSleep Wake DisordersHumansMendelian Randomization AnalysisNarcolepsyRisk FactorsSleep Apnea, ObstructiveSleep Initiation and Maintenance DisordersInsomniaNarcolepsyNon-alcoholic fatty liver diseaseObstructive sleep apnea

Identifiers

PMID41461616

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.