ArticleScientific reports2025
Preoperative hemoglobin level and risk of new-onset atrial fibrillation and flutter after total joint arthroplasty: a retrospective analysis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Novel nomogram for predicting acute kidney injury after cardiac surgery.Journal of thoracic disease · 2026Article
- A review of bloodstream infections-pathogens, pathogenesis, diagnostic strategies, treatment methods-challenges and future aspects.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Review
- Serum vitamin B12 levels and 90-day outcomes in hospitalized patients with dementia: A cohort study.Medicine · 2026Article
- Information theory and thermal properties of an extended cosine hyperbolic potential model.Scientific reports · 2026Article
- Magnesium deficiency and long-term incident dementia among COVID-19 survivors: a propensity score-matched cohort study.Frontiers in nutrition · 2026Article
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Authors and funding
6 authors.
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Abstract
This retrospective cohort study investigated whether low preoperative hemoglobin levels increase postoperative atrial fibrillation and flutter (POAF) risk following elective total joint arthroplasty. Using the TriNetX Analytics Network Platform, we analyzed patients aged ≥ 40 years undergoing primary knee or hip arthroplasty under general anesthesia between 2010 and 2024. Patients were categorized into low hemoglobin (8-12 g/dL) and control (> 12 g/dL) groups. After 1:1 propensity score matching yielded 22,996 pairs, Cox regression analysis revealed significantly higher six-month POAF incidence in the low hemoglobin group (1.4% vs. 0.97%; HR 1.39, 95% CI 1.17-1.65, p < 0.001). The low hemoglobin group also demonstrated increased all-cause mortality (1.0% vs. 0.47%; HR 2.10, p < 0.001) and ICU admissions (1.4% vs. 0.84%; HR 1.65, p < 0.001). Even mild hemoglobin reduction (10-12 g/dL) significantly elevated POAF risk (HR 1.35, p = 0.001). Temporal analysis showed peak POAF risk occurring 30-180 days postoperatively, with effects persisting up to three years. These findings establish low preoperative hemoglobin as an independent, clinically significant risk factor for POAF and adverse outcomes following orthopedic surgery, suggesting preoperative anemia correction may be a valuable intervention for improving postoperative outcomes.
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