Evidence map›Paper›PMID 41462022›Full record

ArticleNature communications2025

Stress induces oxytocin-Gαi-dependent remodeling of astrocytes to shape neuronal response in the amygdala.

Angel Baudon, Valentin Grelot, Kai-Yi Wang, Ferdinand Althammer, Clémence Denis, Pierre Riché-Piotaix, Azmal Syed Ali, Yudong Yan, Fernando Castillo Díaz, Francesca Piacentini and 30 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Astrocytes mediate a positive feedback loop for oxytocin.bioRxiv : the preprint server for biology · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

Angel Baudon *Centre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France.ORCID http://orcid.org/0000-0003-4125-9476
Valentin Grelot *Centre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France.
Kai-Yi Wang *Centre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France.
Ferdinand Althammer *Institute of Human Genetics, Heidelberg University, Heidelberg, Germany.
Clémence DenisCentre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France.
Pierre Riché-PiotaixCentre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France.
Azmal Syed AliGerman Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0003-3024-9379
Yudong YanZentrum für Experimentelle Neurologie, Department of Neurology, Inselspital University Hospital Bern, Bern, Switzerland.
Fernando Castillo DíazDepartment of Behavioural and Molecular Neurobiology, University of Regensburg, Regensburg, Germany.
Francesca PiacentiniCentre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France.
Etienne Clauss CreusotCentre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France.
Volodya HovhannisyanCentre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France.
Tim SchubertInstitute of Human Genetics, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0009-0003-1696-4402
Annabel C KleinwaechterInstitute of Human Genetics, Heidelberg University, Heidelberg, Germany.
Eva M EisemannInstitute of Human Genetics, Heidelberg University, Heidelberg, Germany.
Jabir Aliyu MuhammadInstitute of Human Genetics, Heidelberg University, Heidelberg, Germany.
Jemima HelenInstitute of Human Genetics, Heidelberg University, Heidelberg, Germany.
Tom LakomyUniversité Paris-Saclay, CNRS, Institut des Neurosciences Paris-Saclay, Saclay, Paris, France.
Quirin KrabichlerDepartment of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, German Center for Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0003-1431-5591
Rachel BretonCenter for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, PSL-Neuro, Université PSL, Paris, France.
Virginie AndryCentre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France.
Maria-Angeles Carrillo-de SauvageUniversité Paris-Saclay, CNRS, Institut des Neurosciences Paris-Saclay, Saclay, Paris, France.ORCID http://orcid.org/0000-0002-3312-5956
Valérie DemaisCentre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France.
Aurélia CèsCentre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France.
Felix FrankeInstitute of Human Genetics, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0009-0006-1696-3030
Franziska SchommerInstitute of Human Genetics, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0009-0001-4966-3986
Mélanie KremerCentre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France.
Barbara Di BenedettoDepartment of Neuro-Glial Neurobiology, University of Regensburg, Regensburg, Germany.
Yannick GoumonCentre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France.
Christian P SchaafInstitute of Human Genetics, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-2148-7490
Valery GrinevichDepartment of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, German Center for Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0002-6337-8866
Nathalie RouachCenter for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, PSL-Neuro, Université PSL, Paris, France.ORCID http://orcid.org/0000-0002-5574-888X
Pascal DarbonCentre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France.ORCID http://orcid.org/0000-0002-7772-9604
Inga D NeumannDepartment of Behavioural and Molecular Neurobiology, University of Regensburg, Regensburg, Germany.
Antoine AdamantidisZentrum für Experimentelle Neurologie, Department of Neurology, Inselspital University Hospital Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0003-2531-5175
Marta BusnelliNational Research Council, Institute of Neuroscience, Vedano al Lambro, Italy.ORCID http://orcid.org/0000-0003-3387-2190
Lucile BenhaimUniversité Paris-Saclay, CNRS, Institut des Neurosciences Paris-Saclay, Saclay, Paris, France.
Jeroen KrijgsveldGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Frank W PfriegerCentre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France.ORCID http://orcid.org/0000-0001-7085-1431
Alexandre CharletCentre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France. acharlet@unistra.fr.ORCID http://orcid.org/0000-0003-4837-3706

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anticipated reactions to stressful situations are vital for the survival and well-being of organisms, and abnormal reactions results in stress-related disorders. The neuropeptide oxytocin is a key modulator ensuring well-adapted stress responses. Oxytocin acts on both neurons and astrocytes, but the molecular and cellular mechanisms mediating stress response remain poorly understood. Here, we focus on the amygdala, a crucial hub that integrates and processes sensory information through oxytocin-dependent mechanisms. Using an acute stress paradigm in mice, genetic and pharmacological manipulations combined with proteomic, morphological, electrophysiological and behavioral approaches, we reveal that oxytocinergic modulation of the freezing response to stress is mediated by transient Gαi-dependent retraction of astrocytic processes, followed by enhanced neuronal sensitivity to extracellular potassium in the amygdala. Our findings elucidate a pivotal role for astrocytes morphology-dependent modulation of brain circuits that is required for proper anticipated behavioral response to stressful situations.

Indexed as

AmygdalaAstrocytesGTP-Binding Protein alpha Subunits, Gi-GoNeuronsOxytocinStress, PsychologicalAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutPotassiumReceptors, OxytocinGTP-Binding Protein alpha Subunits, Gi-GoOxytocinPotassiumReceptors, Oxytocin

Identifiers

PMID41462022
PMCPMC12877189

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.