ArticleJournal of orthopaedic surgery and research2025
miR-202-5p mitigates the advancement of osteoporosis through the regulation of PTEN.
Article in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Robotic-specific patient education reduces preoperative anxiety and improves outcomes after total knee arthroplasty.Journal of robotic surgery · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicroRNAs play a crucial regulatory function in preserving bone remodeling balance and bone metabolic homeostasis.
aimsThis study aimed to detect miR-202-5p expression in OP patients and investigate its role and potential regulatory mechanism in OP development.
methodsqRT-PCR was used to determine miR-202-5p and PTEN expression in serum. The receiver operating characteristic curve was utilized to evaluate miR-202-5p's diagnostic value for OP. CCK-8 and flow cytometry were applied to determine the effects of miR-202-5p on the proliferation and apoptosis of human fetal osteoblasts. Luciferase reporter assay was conducted to verify the targeted binding between miR-202-5p and PTEN.
resultsmiR-202-5p in OP patients was markedly downregulated, and miR-202-5p exhibited high diagnostic value for OP. In vitro experiments showed that miR-202-5p promoted hFOB proliferation, inhibited apoptosis, and enhanced osteogenic differentiation. PTEN expression was significantly higher in OP patients. Prediction via the miRDB database indicated that PTEN might be a target gene of miR-202-5p, which was further confirmed by luciferase assay, verifying their interaction. Additionally, downregulation of PTEN significantly promoted osteogenic differentiation.
conclusionsmiR-202-5p holds promise as a novel potential diagnostic biomarker for OP. miR-202-5p may regulate osteoblast proliferation, apoptosis, and osteogenic differentiation by targeting PTEN, thereby exerting a role in OP.
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