Evidence map›Paper›PMID 41462586›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Chlorogenic Acid Alleviates the Detrimental Effects of Concurrent Hyperglycemia and Chronic Stress on Brain Homeostasis by Modulating Antioxidative Defense in Adult Zebrafish.

Rhea Subba, Gianluca Fasciolo, Adriana Petito, Eugenio Geremia, Maria Teresa Muscari Tomajoli, Amal Chandra Mondal, Gaetana Napolitano, Paola Venditti

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rhea SubbaLaboratory of Cellular and Molecular Neurobiology, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India.ORCID 0000-0003-3275-3341
Gianluca FascioloDepartment of Biology, University of Naples Federico II, 80143 Naples, Italy.ORCID 0000-0002-0707-5617
Adriana PetitoDepartment of Biology, University of Naples Federico II, 80143 Naples, Italy.
Eugenio GeremiaInternational PhD Programme, UNESCO Chair "Environment, Resources and Sustainable Development", Department of Science and Technology, Parthenope University of Naples, 80143 Naples, Italy.ORCID 0000-0003-1464-8409
Maria Teresa Muscari TomajoliInternational PhD Programme, UNESCO Chair "Environment, Resources and Sustainable Development", Department of Science and Technology, Parthenope University of Naples, 80143 Naples, Italy.ORCID 0000-0002-4430-5135
Amal Chandra MondalLaboratory of Cellular and Molecular Neurobiology, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India.ORCID 0000-0003-0491-7804
Gaetana NapolitanoInternational PhD Programme, UNESCO Chair "Environment, Resources and Sustainable Development", Department of Science and Technology, Parthenope University of Naples, 80143 Naples, Italy.ORCID 0000-0001-7400-9217
Paola VendittiDepartment of Biology, University of Naples Federico II, 80143 Naples, Italy.ORCID 0000-0003-0522-1788

Funding

Department of Biotechnology BT/PR38493/TRM/120/465/2020Department of Biotechnology BT/PR47726/CMD/150/26/2023
6 · The paper itself

Abstract

Oxidative stress is a key contributor to diabetes-related cognitive decline and is intensified by diabetes distress (DD), the psychological burden of disease management. DD lowers brain levels of nuclear factor erythroid 2-related factor 2 (NRF2), a transcription factor that regulates antioxidant defense. This study examined whether chlorogenic acid (CGA), a polyphenolic NRF2 activator, could counteract oxidative and astroglial dysfunctions in adult zebrafish subjected to chronic unpredictable mild stress (CUMS) combined with dextrose, a model mimicking DD. Zebrafish were treated with CGA (50, 100, or 200 mg/kg), and the levels of NRF2 protein and mRNA, along with its regulator

Indexed as

astrogliachlorogenic aciddiabetes distresshyperglycemiaoxidative stresszebrafish

Identifiers

PMID41462586
PMCPMC12730118

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.