ReviewBiomedicines2025
Telomere Length Abnormality: Investigating Approaches and Correlations with Cancer, Bone Marrow Failure and Hematological Malignancies.
Review in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Authors and funding
8 authors.
Funding
Abstract
Proper telomere maintenance is crucial for ensuring healthy cellular function. Telomeres have a tendency to reduce in length with cellular aging. Moreover several factors may promote telomere attrition. Other conditions, primarily due to genetic and inherited origins, can be characterized by unusually long telomeres. Both shortening and elongation of telomere length (TL) may lead to increased risk of cancer occurrence or cancer progression. Additionally, some hematopoietic dysfunctions may also be associated with telomere abnormalities. This review is aimed to describe and discuss main aspects of TL, in relation to carcinogenesis. The initial section describes main current methods for TL assessment, since the accurate and reliable TL measurements is a crucial issue in TL research. The various studies describing the association between TL and cancer risk are then reported and critically illustrated, with special interest on TL shortening in hematological malignancies, as well as in some peculiar non-malignant dysfunctions. Hence, a systematic analysis of the broad contribution of TL to cancer development is extensively appraised.
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