Evidence map›Paper›PMID 41463155›Full record

ArticleCancers2025

Low Neutrophil-to-Lymphocyte Ratio Combined with High Intraepithelial CD8+ Tumour-Infiltrating Lymphocytes Within the Tumour Microenvironment Is a Prominent Prognostic Factor in Advanced Epithelial Ovarian Cancer.

Mami Shibahara, Hiroshi Harada, Tomoko Kurita, Midori Murakami, Yoshikazu Harada, Toru Hachisuga, Shohei Shimajiri, Toshiyuki Nakayama, Yusuke Matsuura, Kiyoshi Yoshino

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mami ShibaharaDepartment of Obstetrics and Gynaecology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
Hiroshi HaradaDepartment of Obstetrics and Gynaecology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
Tomoko KuritaDepartment of Obstetrics and Gynaecology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.ORCID 0000-0003-3877-7520
Midori MurakamiDepartment of Obstetrics and Gynaecology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
Yoshikazu HaradaDepartment of Pathology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.ORCID 0000-0002-8845-2743
Toru HachisugaDepartment of Obstetrics and Gynaecology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.ORCID 0000-0003-2888-2538
Shohei ShimajiriDepartment of Pathology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
Toshiyuki NakayamaDepartment of Pathology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
Yusuke MatsuuraDepartment of Nursing of Human Broad Development, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.ORCID 0000-0002-1053-2444
Kiyoshi YoshinoDepartment of Obstetrics and Gynaecology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesTumour-infiltrating lymphocytes (TILs) significantly influence the prognosis of epithelial ovarian cancer (EOC). Advanced EOCs often cause neutrophilia, ascites, and malnutrition. The neutrophil-to-lymphocyte ratio (NLR) serves as a marker of systemic inflammation. This study investigated the prognostic significance of pre-treatment NLR and TILs in advanced EOCs.

methodsOverall, 101 advanced EOCs (stages III-IV, FIGO 2014) were treated between 2005 and 2020. Based on pathological findings, advanced EOCs were classified as having high or low TILs using CD8 and CD4 immunostaining. The tumour proportion score was calculated to determine PD-L1 expression. The number of marker-positive cells was counted using HALO. Progression-free survival and overall survival (OS) were compared between the high- and low-NLR groups based on TILs levels.

resultsClinicopathological characteristics, including age, FIGO stage, histological subtype, and postoperative residual disease, did not significantly differ among the four groups defined by NLR and intra-epithelial CD8+ TILs (CD8+ iTILs). Multivariate analysis of OS revealed that NLR and CD8+ iTILs were independent prognostic factors, and no correlation was observed between them. The 5-year OS rates were 82.2% in the low NLR-high CD8+ iTILs group (

conclusionsIn advanced EOCs, the status of tumour-localised immunity and pre-treatment systemic inflammation influenced long-term prognosis.

Indexed as

cancer cachexiaepithelial ovarian cancerneutrophil-to-lymphocyte ratiotumour-infiltrating lymphocyte

Identifiers

PMID41463155
PMCPMC12730443

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.