Evidence map›Paper›PMID 41463182›Full record

ArticleCancers2025

Identification of Novel Susceptibility Genes for Early-Onset Colorectal Cancer Through Germline Rare Variant Burden Testing.

Ruocen Song, Reger R Mikaeel, Zhongping He, Mehgan Horsnell, Wendy Uylaki, Weimin Meng, Nicola K Poplawski, Bernd Wollnik, Yun Li, Jinghua Feng and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Ruocen SongDepartment of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
Reger R MikaeelDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Zhongping HeDepartment of Biostatistics, University of Florida, Gainesville, FL 32611, USA.ORCID 0009-0008-8249-0213
Mehgan HorsnellDepartment of Haematology and Oncology, The Queen Elizabeth Hospital, Woodville, SA 5011, Australia.
Wendy UylakiDepartment of Haematology and Oncology, The Queen Elizabeth Hospital, Woodville, SA 5011, Australia.ORCID 0009-0003-2937-863X
Weimin MengDepartment of Health Outcomes and Biomedical Informatics, University of Florida, Gainesville, FL 32611, USA.
Nicola K PoplawskiAdult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.ORCID 0000-0002-9372-3325
Bernd WollnikInstitute of Human Genetics, University Medical Center Göttingen, 37075 Göttingen, Germany.
Yun LiInstitute of Human Genetics, University Medical Center Göttingen, 37075 Göttingen, Germany.
Jinghua FengCentre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA 5001, Australia.
Hamish S ScottCentre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA 5001, Australia.ORCID 0000-0002-5813-631X
Yufeng ShenDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Chen WangDepartment of Biostatistics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Rui YinDepartment of Health Outcomes and Biomedical Informatics, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0002-1403-0396
Yousong DingDepartment of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development, University of Florida, Gainesville, FL 32611, USA.
Xavier LlorInternal Medicine, Yale School of Medicine, Yale University, New Haven, CT 06520, USA.ORCID 0000-0002-6259-185X
Wendy K ChungDepartment of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0003-3438-5685
Eric SmithDepartment of Haematology and Oncology, The Queen Elizabeth Hospital, Woodville, SA 5011, Australia.ORCID 0000-0003-2958-3492
Timothy J PriceDepartment of Haematology and Oncology, The Queen Elizabeth Hospital, Woodville, SA 5011, Australia.ORCID 0000-0002-3922-2693
Joanne P YoungDepartment of Haematology and Oncology, The Queen Elizabeth Hospital, Woodville, SA 5011, Australia.
Xiao FanDepartment of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.

Funding

Engineering Native E. coli to Detect, Report, and Treat Colorectal CancerU01CA265719 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZARRINPAR, AMIR · 2021 to 2025
$3.1M
New quantitative approaches to interpret variant pathogenicityR00HG011490 · NHGRI · UNIVERSITY OF FLORIDA · PI FAN, XIAO · 2023 to 2025
$727k
NCI NIH HHS U01 CA265719NHGRI NIH HHS R00 HG011490NIH HHS 5R00HG011490-04NIH HHS 5U01CA265719-05
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

colorectal cancerearly-onset colorectal cancergermline variantsoncogenesrare variant burden testtumor suppressor genes

Identifiers

PMID41463182
PMCPMC12731108

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.