Evidence map›Paper›PMID 41463193›Full record

ArticleCancers2025

Real-World Impact of Metformin on Outcomes in Patients with Deficient DNA Mismatch Repair and Microsatellite Instability (dMMR/MSI) Colorectal Cancer Treated with Immune Checkpoint Inhibitors.

Garima Gupta, Negar Sadeghipour, Fuat Bicer, Andrew Elliott, Andrew Hinton, Emil Lou, Ari M Vanderwalde, Ahmet Anil Ozluk, Moh'd M Khushman, Midhun Malla and 4 more

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Garima GuptaDivision of Hematology and Oncology, Department of Medicine, O'Neal Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, AL 35233, USA.ORCID 0000-0002-8730-006X
Negar SadeghipourCaris Life Sciences, Phoenix, AZ 85040, USA.
Fuat BicerDepartment of Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Andrew ElliottCaris Life Sciences, Phoenix, AZ 85040, USA.ORCID 0000-0001-8494-8031
Andrew HintonCaris Life Sciences, Phoenix, AZ 85040, USA.ORCID 0009-0000-2744-9308
Emil LouDivision of Hematology, Oncology and Transplantation, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA.ORCID 0000-0002-1607-1386
Ari M VanderwaldeCaris Life Sciences, Phoenix, AZ 85040, USA.
Ahmet Anil OzlukDivision of Hematology and Oncology, Department of Medicine, O'Neal Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, AL 35233, USA.ORCID 0000-0002-1049-330X
Moh'd M KhushmanDivision on Oncology, Washington University in St. Louis/Siteman Cancer Center, St. Louis, MO 63110, USA.ORCID 0000-0002-3095-5073
Midhun MallaDivision of Hematology and Oncology, Department of Medicine, O'Neal Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Darryl OutlawDivision of Hematology and Oncology, Department of Medicine, O'Neal Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Syed Qasim HussainiDivision of Hematology and Oncology, Department of Medicine, O'Neal Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Bassel F El-RayesDivision of Hematology and Oncology, Department of Medicine, O'Neal Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, AL 35233, USA.ORCID 0000-0002-2661-5746
Mehmet AkceDivision of Hematology and Oncology, Department of Medicine, O'Neal Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, AL 35233, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

colorectal cancerDNA mismatch repairimmune checkpoint inhibitorsmetforminmicrosatellite instability

Identifiers

PMID41463193
PMCPMC12731130

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.