Evidence map›Paper›PMID 41463204›Full record

ReviewCancers2025

The Pathogenesis of the Neurofibroma-to-Sarcoma Transition in Neurofibromatosis Type I: From Molecular Profiles to Diagnostic Applications.

Sabrina Busciglio, Ilenia Rita Cannizzaro, Anita Luberto, Antonietta Taiani, Barbara Moschella, Enrico Ambrosini, Sofia Cesarini, Mirko Treccani, Cinzia Azzoni, Lorena Bottarelli and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sabrina BusciglioMedical Genetics, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0009-0003-4509-7694
Ilenia Rita CannizzaroMedical Genetics, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0009-0009-6816-6131
Anita LubertoMedical Genetics, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Antonietta TaianiMedical Genetics, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0009-0004-4282-6801
Barbara MoschellaMedical Genetics, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Enrico AmbrosiniMedical Genetics, University Hospital of Parma, 43126 Parma, Italy.
Sofia CesariniMedical Genetics, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Mirko TreccaniDepartment of Food and Drug, University of Parma, 43126 Parma, Italy.ORCID 0000-0002-9175-9455
Cinzia AzzoniPathology Unit, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Lorena BottarelliPathology Unit, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Domenico CorradiPathology Unit, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Vera UlianaMedical Genetics, University Hospital of Parma, 43126 Parma, Italy.
Davide MartoranaMedical Genetics, University Hospital of Parma, 43126 Parma, Italy.ORCID 0000-0002-7572-7031
Valeria BariliMedical Genetics, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0001-7711-2156
Antonio PercesepeMedical Genetics, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0002-3268-6786

Funding

Ministero dell'università e della ricerca Project Code P2022M9SRW and CUP Code D53D23016670001.
6 · The paper itself

Abstract

Neurofibromatosis type 1 (NF1) predisposes to a spectrum of peripheral nerve sheath tumors, ranging from benign plexiform neurofibromas (PN) to atypical neurofibromatous neoplasms of uncertain biological potential (ANNUBP) and malignant peripheral nerve sheath tumors (MPNST). Tumorigenesis follows a multistep molecular cascade initiated by biallelic

Indexed as

epigenetic dysregulationgenomic profilingliquid biopsymalignant peripheral nerve sheath tumorsNeurofibromatosis type 1omics analysis

Identifiers

PMID41463204
PMCPMC12730839

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.