Evidence map›Paper›PMID 41463293›Full record

ArticleBiomolecules2025

Human Mutant Dynactin Subunit 1 Causes Profound Motor Neuron Disease Consistent with Possible Mechanisms Involving Axonopathy, Mitochondriopathy, Protein Nitration, and T-Cell-Mediated Cytolysis.

Victor Xie, Maria Clara Franco, Lee J Martin

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Victor XieDepartment of Pathology, Neuropathology Division, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0009-0001-7562-303X
Maria Clara FrancoCenter for Translation Science, Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, FL 33199, USA.ORCID 0000-0002-7971-9805
Lee J MartinDepartment of Pathology, Neuropathology Division, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-8961-7020

Funding

Redox Signaling in NeurofibromatosisR01NS102479 · NINDS · OREGON STATE UNIVERSITY · PI FRANCO, MARIA CLARA · 2019 to 2023
$1.7M
NIH HHS 1R01NS107417-04A1NINDS NIH HHS R01 NS102479
6 · The paper itself

Abstract

Mutations in the gene encoding the p150 subunit of the dynactin complex (

Indexed as

AxonsDynactin ComplexMitochondrial DiseasesMotor Neuron DiseaseMotor NeuronsProtein Processing, Post-TranslationalTyrosineAnimalsAnterior Horn CellsFemaleHumansMaleMiceMice, TransgenicMitochondrial DynamicsMutation3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone3-nitrotyrosineDCTN1 protein, humanDynactin ComplexQuinazolinonesTyrosineALSCD8cell deathFasheat-shock protein-90mitochondriamotor neuronT cell

Identifiers

PMID41463293
PMCPMC12730482

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.