Evidence map›Paper›PMID 41463307›Full record

ArticleBiomolecules2025

Microbial Biotransformation of the Sesquiterpene Carotol: Generation of Hydroxylated Metabolites with Potential Cytotoxic and Target-Specific Binding Activities.

Hanan G Sary, Mohammed A Khedr, Mohamed M Radwan, Mickey Vinodh, Khaled Y Orabi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Foods (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hanan G SaryDepartment of Pharmaceutical Chemistry, College of Pharmacy, Kuwait University, Safat 13110, Kuwait.ORCID 0009-0007-2933-8434
Mohammed A KhedrDepartment of Pharmaceutical Chemistry, College of Pharmacy, Kuwait University, Safat 13110, Kuwait.
Mohamed M RadwanDepartment of Biomolecular Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.ORCID 0000-0002-7393-8601
Mickey VinodhResearch Sector Project Units, Faculty of Science, Kuwait University, Safat 13060, Kuwait.
Khaled Y OrabiDepartment of Pharmaceutical Chemistry, College of Pharmacy, Kuwait University, Safat 13110, Kuwait.ORCID 0000-0003-0262-4637

Funding

Kuwait University GS01/01, GS01/03, GS03/08
6 · The paper itself

Abstract

Carotol, the major sesquiterpene alcohol in carrot essential oil, possesses notable cytotoxic activity against various cancer cell lines, yet its metabolic fate remains poorly understood. This study explored microbial biotransformation as a tool for generating novel carotol derivatives with potential pharmacological value. Seventeen microbial strains were screened, with

Indexed as

Polycyclic SesquiterpenesSesquiterpenesAntineoplastic AgentsBiotransformationCell Line, TumorHumansHydroxylationMolecular Docking SimulationAntineoplastic AgentscarotolPolycyclic SesquiterpenesSesquiterpenesAbsidia coeruleacarotolcarrot seed essential oilcytotoxic activityhydroxydaucolmicrobial biotransformationmolecular dockingsesquiterpene alcohol

Identifiers

PMID41463307
PMCPMC12731232

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.